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  • Innovations in Biotechnology and Medical Sciences

    2020 Nobel for Hepatitis C Virus discovery

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Americans Harvey J Alter and Charles M Rice, and British scientist Michael Houghton were awarded the Nobel Prize for Medicine or Physiology on Monday for the discovery of the hepatitis C virus.

    Try this PYQ:

    Q.Which one of the following statements is not correct? (CSP 2019)

    (a) Hepatitis B virus is transmitted much like HIV.

    (b) Hepatitis B. unlike Hepatitis C, does not have a vaccine.

    (c) Globally, the number of people infected with Hepatitis B and C viruses arc several times more than those infected with HIV.

    (d) Some of those infected with Hepatitis B and C viruses do not show the symptoms for many years.

    Hepatitis C Virus

    • Hepatitis C virus (HCV) is a bloodborne virus and causes liver diseases. It refers to an inflammatory condition of the liver.
    • The novel virus caused several deaths in the 1960s and 1970s — but remained unknown until its discovery in the late 1980s.

    What are other Hepatitis Viruses?

    • Before the discovery of the Hepatitis C virus, two other viruses were known to cause hepatitis in patients.
    • The Hepatitis A virus was known to spread mainly through contaminated food and water and caused a relatively milder form of liver inflammation.
    • Hepatitis B, discovered in the 1960s, was known to transmit mainly through infected blood and caused a more serious form of the disease.
    • Incidentally, the discovery of the Hepatitis B virus too was rewarded with a Nobel Prize in Medicine, given to Baruch Blumberg in 1976. There are vaccines available for this disease now.

    How Hepatitis C came to observation?

    • The discovery and identification of the Hepatitis B virus facilitated the development of a diagnostic test to detect its presence in blood.
    • Thereafter, only blood sanitized from this virus would be given to patients, but it was observed that even this sanitized blood was able to prevent only 20% of the blood-borne hepatitis cases.
    • It was then that the search for the new virus began.

    How is Hepatitis C treated?

    • Presently there is no vaccine available for HCV. However, it can be treated with antiviral medication.
    • Hepatitis A and B are preventable by vaccine.

    Back2Basics:

    https://www.civilsdaily.com/news/in-news-nobel-prize/

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  • Tax Reforms

    What is Sheltering of Taxes?

    Prelims Only | Economics | Mains Paper 3: Indian Economy

    This newscard is an excerpt from an original article published in TH.

    We can expect a statement based question comparing Tax Shelters and Tax Heavens.

    What is a Tax Shelter?

    • A tax shelter is a financial vehicle that an individual can use to help them lower their tax obligation and, thus, keep more of their money.
    • It is a legal way for individuals to “stash” their money and avoid getting it taxed.
    • A tax shelter is entirely different from a tax haven because the latter exists outside the country and its legality can, at times, be questionable.
    • A tax shelter, on the other hand, is entirely legal and keeps all monies within an individual’s home country.

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  • Innovations in Biotechnology and Medical Sciences

    What is Ketogenic Diet?

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Ketogenic or Keto Diet is popularly followed as a weight loss diet across the world.

    Try this PYQ:

    Q.Regular intake of fresh fruits and vegetables is recommended in the diet since they are a good source of antioxidants. How do antioxidants help a person maintain health and promote longevity? (CSP 2014)

    (a) They activate the enzymes necessary for vitamin synthesis in the body and help prevent vitamin deficiency.

    (b) They prevent excessive oxidation of carbohydrates, fats and proteins in the body and help avoid unnecessary wastage of energy.

    (c) They neutralize the free radicals produced in the body during metabolism.

    (d) They activate certain genes in the cells of the body and help delay the ageing process.

    What is Ketogenic Diet?

    • The Keto Diet is one of the most popular weight-loss diets the world over.
    • It consists of a high-fat, moderate-protein and low-carb diet.
    • It helps in weight loss by achieving ketosis — a metabolic state where the liver burns body fat and provides fuel for the body, as there is limited access to glucose.

    What constitutes a keto diet?

    • A classic keto generally requires that 90 per cent of a person’s calories come from fat, 6 per cent from protein and 4 per cent from carbs.
    • But there are many versions doing the rounds since this one was designed for children suffering from epilepsy to gain control over their seizures.

    How does it impact the body?

    • If we starve the body of carbohydrate, after burning out the glucose, the liver starts breaking down fats for energy.
    • Ketosis is common in all kinds of fasting, but in a keto diet, when one is feeding it by giving a lot of fats from outside without carbs, it can become mildly toxic.
    • It may lead to many nutrient deficiencies such as carbohydrates, proteins, vitamins (especially vitamin A, D, E, & K) and minerals like calcium, phosphorus, sodium.
    • Extreme carbohydrate restriction can lead to hunger, fatigue, low mood, irritability, constipation, headaches, and brain fog, which may last days to weeks

    What impact does it have on our kidneys?

    • Even the moderate increase in protein needs to be carefully monitored, especially in those who are already suffering from chronic kidney disease, as it could lead to kidney failure.
    • One should get a thorough assessment and make sure they have normal kidney function before choosing this diet.
    • This diet could lead to increased stress on the kidneys and result in kidney stones, as they are made to work overtime.

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  • Modern Indian History-Events and Personalities

    Personality in news: Shyamji Krishna Varma

    Prelims Only | | Mains Paper 1: Modern Indian History

    PM has paid rich tributes to revolutionary freedom fighter Shyamji Krishna Varma on his birth anniversary.

    Try this PYQ:

    Q. The Ghadr (Ghadar) was a –

    (a) Revolutionary association of Indians with headquarters at San Francisco.

    (b) Nationalist organization operating from Singapore

    (c) Militant organization with headquarters at Berlin

    (d) Communist movement for India’s freedom with head-quarters at Tashkent

    About Shyamji Krishna Varma

    • SK Varma (1857–1930) was an Indian revolutionary fighter, a patriot, lawyer and journalist who founded the Indian Home Rule Society, India House and The Indian Sociologist in London.
    • He was a noted scholar in Sanskrit and other Indian languages.
    • He pursued a brief legal career in India and served as the Divan of a number of Indian princely states in India.
    • He had, however, differences with Crown authority, was dismissed following a supposed conspiracy of local British officials at Junagadh and chose to return to England.
    • An admirer of Dayanand Saraswati’s approach of cultural nationalism, and of Herbert Spencer, Krishna Varma believed in Spencer’s dictum: “Resistance to aggression is not simply justified, but imperative”.

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  • Coronavirus – Health and Governance Issues

    [pib] Coalition of Epidemic Preparedness for Innovation (CEPI)

    PIB | Governance | Mains Paper 2: Health & Education

    Translational Health Science And Technology Institute (THSTI), an autonomous institute of the Department of Biotechnology, has now been recognized by Coalition of Epidemic Preparedness for Innovation (CEPI) as one of the Global Network of Laboratories for centralized assessment of COVID 19 Vaccines.

    Note: CEPI is neither a WHO subsidiary nor a UN body .

    Coalition of Epidemic Preparedness for Innovation (CEPI)

    • The CEPI is a foundation that takes donations to finance independent research projects to develop vaccines against emerging infectious diseases (EID).
    • It is focused on the WHO’s “blueprint priority diseases.
    • These diseases include the Middle East respiratory syndrome-related coronavirus (MERS-CoV), the SARS coronavirus 2 the Nipah virus, the Lassa fever virus, and the Rift Valley fever virus, as well as the Chikungunya virus and the hypothetical, unknown pathogen “Disease X”.
    • CEPI investment also requires “equitable access” to the vaccines during outbreaks.
    • CEPI was conceived in 2015 and formally launched in 2017 at the World Economic Forum (WEF) in Davos, Switzerland.

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  • Insolvency and Bankruptcy Code

    Need for streamlining the Insolvency and Bankruptcy Code

    | Economics | Mains Paper 3: Indian Economy

    The article analyses the impact of Insolvency and Bankruptcy Code (IBC) on the insolvency resolution and on Indian economy.

    Measures that will improve investment

    1)  IBC: transforming insolvency resolution

    • IBC replaced inefficient bankruptcy law regime and has transformed insolvency resolution in India.
    • The IBC has focused on time-bound resolution, rather than liquidation.
    • IBC acts as an empowering tool to support companies falling within its ambit.
    • It has successfully instilled confidence in the corporate resolution methodology.
    • It has allowed credit to flow more freely to and within India while promoting investor and investee confidence.
    • The IBC is both flexible and dynamic, which makes it impactful, given how forward thinking the concept of an omnibus legislation of its nature actually is.
    • Through the Insolvency and Bankruptcy Board of India (IBBI), it has established an unprecedented organisation that both regulates and develops insolvency policy, and assesses market realities.

    Impact of IBC

    •  According to the Resolving Insolvency Index, India’s ranking improved to 52 in 2019 from 108 in 2018.
    • Further, the recovery rate improved nearly threefold from 26.5% in 2018 to 71.6% in 2019
    • The overall time taken in recovery also improved nearly three times, coming down from 4.3 years in 2018 to 1.6 years in 2019.

    2) Decriminalisation of minor offences

    • Criminal penalties including imprisonment for minor offences act as major deterrents for investors.
    • The Government of India is also working toward decriminalisation of minor offences.
    • This will significantly reduce the risk of imprisonment for actions or omissions that are not necessarily fraudulent or an outcome of mala fide intent.

    3) Other legislative measures

    • Together with the IBC, following 3 reforms suggests major and multi-dimensional effort by the government.
    • 1) The rolling out of the commercial courts.
    • 2) Commercial divisions and the Commercial Appellate Divisions Act, 2015, to allow district court-level commercial courts.
    • 3) Removal of over 1,500 obsolete and archaic laws.

    Way forward

    • There could perhaps be a look at institutionalising the introduction of a pre-packed insolvency resolution process.
    • This will also help resolve matters expeditiously, outside of the formal court system, and allow resolution even during the COVID-19 altered reality.

    Consider the question “Examine the impact of Insolvency and Bankruptcy Code (IBC) on the insolvency resolution procedure and suggest the further improvements in the IBC.”

    Conclusion

    The IBC has provided a major stimulus to ease of doing business, enhanced investor confidence, and helped encourage entrepreneurship while also providing support to MSMEs. Its further streamlining and strengthening will surely instil greater confidence in both foreign and domestic investors as they look at India as an attractive investment destination.

    B2BASICS

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  • Right To Privacy

    Narco Test and the Issue of Consent

    Explained | Polity | Mains Paper 2: Indian Constitution – historical underpinnings, evolution, features, amendments, significant provisions and basic structure

    Involuntary administration of narco or lie detector tests is an “intrusion” into a person’s “mental privacy,” a Supreme Court judgment of 2010 has held.

    Try this question:

    Q.What are the ethical issues associated with the Lie-detection tests?

    Various Lie detector tests

    (1) Polygraph Test

    • A polygraph test is based on the assumption that physiological responses that are triggered when a person is lying are different from what they would be otherwise.
    • Instruments like cardio-cuffs or sensitive electrodes are attached to the person, and variables such as blood pressure, pulse, respiration, change in sweat gland activity, blood flow, etc., are measured as questions are put to them.
    • A numerical value is assigned to each response to conclude whether the person is telling the truth, is deceiving, or is uncertain.

    (2) Narcoanalysis

    • Narcoanalysis, by contrast, involves the injection of a drug, sodium pentothal, which induces a hypnotic or sedated state.
    • In such a state, the subject’s imagination is neutralized, and they are expected to divulge information that is true.
    • The drug, referred to as “truth serum” in this context, was used in larger doses as anaesthesia during surgery and is said to have been used during World War II for intelligence operations.

    Why these tests are so (in)famous?

    • Investigating agencies seek to employ these tests in the investigation, and are sometimes seen as being a “softer alternative” to torture or “third degree” to extract the truth from suspects.
    • These tests put into consideration the international norms on human rights, the right to a fair trial, and the right against self-incrimination under Article 20(3) of the Constitution.

    Legal status in India

    • In ‘Selvi & Ors vs State of Karnataka & Anr’ (2010), a Supreme Court Bench comprising CJI ruled that no lie detector tests should be administered “except on the basis of the consent of the accused”.
    • Those who volunteer must have access to a lawyer, and have the physical, emotional, and legal implications of the test explained to them by police and the lawyer, the Bench said.
    • It said that the ‘Guidelines for the Administration of Polygraph Test on an Accused’ published by the National Human Rights Commission in 2000, must be strictly followed.
    • The subject’s consent should be recorded before a judicial magistrate, the court said.

    What was the latest Judgement?

    • Involuntary administration of narco or lie detector tests is an “intrusion” into a person’s “mental privacy,” a Supreme Court judgment of 2010 has held.
    • The consequences of such tests on “individuals from weaker sections of society who are unaware of their fundamental rights and unable to afford legal advice” can be devastating.
    • It may involve future abuse, harassment and surveillance, even leakage of the video material to the Press for a “trial by media.”
    • Such tests are an affront to human dignity and liberty and have long-lasting effects.
    • “An individual’s decision to make a statement is the product of a private choice and there should be no scope for any other individual to interfere with such autonomy,” the apex court had held.

    Legal status of its outcome

    • The results of the tests cannot be considered to be “confessions”, because those in a drugged-induced state cannot exercise a choice in answering questions that are put to them.
    • However, any information or material subsequently discovered with the help of such a voluntarily-taken test can be admitted as evidence, the court said.
    • Thus, if an accused reveals the location of a murder weapon in the course of the test, and police later find the weapon at that location, the statement of the accused will not be evidence, but the weapon will be.

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  • Nuclear Diplomacy and Disarmament

    Conference on Disarmament (CD)

    | International Relations | Mains Paper 2: Bilateral, Regional and Global Groupings and agreements involving India

    India has supported the holding of negotiations on a Comprehensive Nuclear Weapons Convention at the Conference on Disarmament (CD). It reiterated its commitment to the disarmament of nuclear weapons in a step-by-step non-discriminatory process.

    List out various factors which are preventing the nuclear disarmaments amongst the nations.

    About the Conference on Disarmament (CD)

    • The CD is a multilateral disarmament forum established by the international community to negotiate arms control and disarmament agreements based at the Palais des Nations in Geneva.
    • The Conference meets annually in three separate sessions in Geneva.
    • The Conference was first established in 1979 as the Committee on Disarmament as the single multilateral disarmament negotiating forum of the international community.
    • It was renamed the Conference on Disarmament in 1984.

    Recent developments from India

    • India has not revised its key principles regarding the weapons in its arsenal.
    • Raksha Mantri has earlier hinted at a possibility of changing the No First Use (NFU) principle by declaring that ‘circumstances’ will determine the “No First Use” stance.

    India stands committed

    • India believes that nuclear disarmament can be achieved through a step-by-step process underwritten by a universal commitment and an agreed multilateral framework.
    • India remains convinced of the need for meaningful dialogue among all states possessing nuclear weapons, for building trust and confidence.
    • India also remains committed to negotiations regarding a Fissile Material Cut-off Treaty in the CD on the basis of the report of the Special Coordinator or CD/1299 which dates to March 24, 1995.

    B2BASICS

    India’s No first use doctrine

    For India, Nuclear weapons are political weapons and not weapons of war and their sole purpose is to deter the use of nuclear weapons by India’s adversaries. India has nit only established itself as a responsible nuclear state, but guided the world about how to be a responsible nuclear state through No first use policy.

    Features of India’s nuclear doctrine:

    1. Building and maintaining a credible minimum deterrent.
    2. A “No First Use” policy i.e. nuclear weapons to be used only in case of any nuclear attack on Indian territory or on Indian forces anywhere.
    3. Non use of nuclear weapons against non-nuclear weapon states.
    4. Nuclear retaliatory attacks to be authorised only by civilian political leadership through the Nuclear Command Authority.
    5. Nuclear retaliation to a first strike will be massive and designed to inflict unacceptable damage.
    6. India may retaliate with nuclear weapons to retaliate against attack  with biological or chemical weapons.
    7. Strict controls on export of nuclear and missile related materials and technologies.
    8. A commitment to goal of nuclear weapon free world.

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  • Roads, Highways, Cargo, Air-Cargo and Logistics infrastructure – Bharatmala, LEEP, SetuBharatam, etc.

    ATAL: World’s Longest Highway Tunnel

    Prelims Only | Economics | Mains Paper 3: Infrastructure: Energy, Ports, Roads, Airports, Railways Etc.

    PM Modi has inaugurated the Atal Tunnel at Rohtang at an altitude of above 3,000 metres in Himachal Pradesh.

    Refer this link to read more about Himalayan passes and rivers

    https://www.civilsdaily.com/the-northern-and-northeastern-mountains-part-1/

    Atal Tunnel

    • The 9.02 km-long-tunnel, built by the Border Roads Organisation (BRO), is the world’s longest highway tunnel and connects Manali to Lahaul-Spiti valley.
    • It provides all-weather connectivity to the landlocked valley of Lahaul-Spiti, which remains cut-off for nearly six months in a year as the Rohtang Pass is usually snow-bound between November and April.
    • Before the tunnel construction, the Lahaul Valley used to remain closed for vehicular movement due to bad weather conditions.
    • It reduces the distance by 46 km between Manali and Leh and the travel time by about 4 to 5 hours. It is expected to boost tourism and winter sports in the region.
    • The tunnel, also significant from the military logistics viewpoint, will provide better connectivity to the armed forces in reaching Ladakh.

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  • Indian Missile Program Updates

    Shaurya Missile and India’s K missiles family

    Prelims Only | Security Issues | Mains Paper 3: Achievements Of Indians In S&T

    A successful trial of the nuclear-capable Shaurya missile was conducted by India.

    Shaurya Missile

    • Shaurya is a land-based parallel of the submarine-launched K-15 missile.
    • It is a land variant of short-range SLBM K-15 Sagarika, which has a range of at least 750 kilometres.
    • These ballistic weapons belong to the K missile family — codenamed after late Dr APJ Abdul Kalam — which is launched from Arihant class of nuclear submarines.
    • Because these missiles are to be launched from submarines, they are lighter, smaller and stealthier than their land-based counterparts; the Agni series.

    A look at what this family of missiles is their strategic importance as a nuclear deterrent and their recent tests.

    K Family of missiles

    • The K family of missiles is primarily Submarine Launched Ballistic Missiles (SLBMs), which have been indigenously developed by DRDO.
    • These are named after Dr Kalam, the central figure in India’s missile and space programmes who also served as the 11th President of India.
    • The development of this naval platform launched missiles began in the late 1990s as a step towards completing India’s nuclear triad (land, sea and air-based).

    Strategic importance of SLBMs

    • The capability of being able to launch nuclear weapons submarine platforms has great strategic importance in the context of achieving a nuclear triad, especially in the light of ‘no first use’ policy of India.
    • The sea-based underwater nuclear-capable assets significantly increase the second strike capability of a country and thus boosts its nuclear deterrence.
    • These submarines can not only survive the first strike by the adversary but also can launch a strike in retaliation thus achieving Credible Nuclear Deterrence.
    • The development of these capabilities is important in light of India’s relations with the two neighbours China and Pakistan.

    Try this PYQ now:

    What is “Terminal High Altitude Area Defense (THAAD)”, sometimes seen in the news? (CSP 2018)

    (a) An Israeli radar system

    (b) India’s indigenous anti-missile programme

    (c) An American anti-missile system

    (d) A defence collaboration between Japan and South Korea

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