From UPSC perspective, the following things are important :
Mains level: Safety Law and Guidelines; Importance of Safety Audits;
Why in the News?
On August 21, 2024, a deadly explosion at the Escientia plant in Atchutapuram SEZ killed 17 workers and injured over 50, triggered by a solvent leak involving MTBE. The incident, part of a troubling safety trend, has prompted a government inquiry and calls for stricter safety regulations, particularly due to the exemption from regular inspections for SEZ units.
Previous Incidents: This accident is part of a troubling pattern, as it follows another major explosion in the same SEZ last year, and recalls a deadly styrene vapour leak incident in 2020 that killed 12 people.
Government Response: The Andhra Pradesh government has ordered a high-level inquiry into the incident. Chief Minister N. Chandrababu Naidu has expressed condolences and promised support for the victims’ families.
Importance of Safety Audits
Preventing Future Accidents: Regular safety audits can help identify potential hazards and ensure compliance with safety regulations, reducing the risk of catastrophic incidents.
Accountability: Audits enforce accountability among management to adhere to safety standards, promoting a culture of safety within organizations.
Regulatory Compliance: Conducting safety audits helps organizations ensure compliance with local, state, and national safety regulations.
Public Trust: Enhancing safety measures and transparency can restore public confidence in industrial operations, particularly in regions prone to industrial accidents.
Safety Law and Guidelines:
Factories Act, 1948: Governs worker safety in factories, mandating safety audits and safety officer appointments. Requires safety committees with management and employee reps to address hazards.
IS 14489:1998: Provides guidelines for occupational safety and health audits, focusing on compliance, deviations, and safety management effectiveness across sectors.
Occupational Safety, Health and Working Conditions Code, 2020: Consolidates labor laws, mandates regular safety audits for hazardous processes, and grants inspectors authority to enforce compliance.
CIMAH Rules: Require industries with hazardous processes to prepare safety reports and conduct regular audits to prevent major accidents, enforced by state safety authorities.
Integrated Guidance Framework for Chemicals Safety: Offers guidance for safety audits in handling hazardous chemicals, emphasizing compliance with MSIHC Rules and robust audit practices.
Note:
IS 14489:1998 is an Indian Standard titled “Code of Practice on Occupational Safety and Health Audit.” It provides comprehensive guidelines for conducting occupational safety and health audits in various workplaces.
Way forward:
Implement Regular Safety Audits: Enforce routine safety audits for all industrial units, including SEZs, to identify hazards and ensure compliance with safety standards, thus preventing future incidents and promoting a culture of safety.
Strengthen Regulatory Oversight: Close regulatory gaps by applying safety standards uniformly across all sectors, including exempted units, and enhance transparency and accountability in safety practices to restore public trust.
From UPSC perspective, the following things are important :
Prelims level: Various space missions mentioned
Mains level: NA
Why in the News?
Since Chandrayaan 3’s successful moon landing on August 23, 2023 and its declaration of National Space Day, ISRO has remained highly active with several key missions, despite a quieter phase at Sriharikota.
From UPSC perspective, the following things are important :
Prelims level: World Audio Visual and Entertainment Summit (WAVES)
Why in the News?
Union Minister of Information and Broadcasting has launched 25 challenges as part of the ‘Create in India Challenge – Season 1’ for the World Audio Visual & Entertainment Summit (WAVES).
About WAVES
It is an international summit organized by the Ministry of Information & Broadcasting, Government of India.
The first edition will take place from 20-24 November 2024 in Goa.
The summit will be hosted in Goa in collaboration with the State Government of Goa.
The Entertainment Society of Goa will act as the Nodal Agency for the event, following an MOU with Ministry of Information & Broadcasting.
It is supported by industry partners like the Federation of Indian Chambers of Commerce & Industry (FICCI) and the Confederation of Indian Industry (CII).
Purpose:
WAVES aims to be a pivotal forum for fostering dialogue, trade collaboration, and innovation within the evolving media and entertainment industry.
The summit will showcase India as a hub for innovation and excellence in the media and entertainment sector, attract investments, and position India as a global leader in the entertainment business.
Location & Collaboration:
WAVES is designed to promote sustainable growth in the media and entertainment industry.
It will help attract global trade and investment to India, positioning the country as a key player in the global entertainment landscape.
The summit will bring together industry leaders, stakeholders, and innovators to explore new opportunities, tackle challenges, and shape the future of the sector.
PYQ:
[2014] Though 100 percent FDI is already allowed in non-news media like a trade publication and general entertainment channel, the government is mulling over the proposal for increased FDI in news media for quite some time. What difference would an increase in FDI make? Critically evaluate the pros and cons.
From UPSC perspective, the following things are important :
Prelims level: Orangutan Diplomacy
Why in the News?
Malaysia, after initially introducing its version of soft power called “Orangutan Diplomacy” following China’s successful “panda diplomacy,” has now reversed its decision.
What is Orangutan Diplomacy?
It is a Malaysian strategy that seeks to use orangutan conservation as a tool of soft power, inspired by China’s “panda diplomacy.”
It had first announced plans to gift orangutans (IUCN Status: Critically Endangered) to palm oil-buying countries.
It engages other countries in conservation efforts, focusing on symbolic adoptions rather than sending animals abroad.
Reasons behind:
Palm Oil Industry Criticism: Malaysia faces criticism for deforestation due to palm oil plantations, threatening orangutans.
Enhance Image: It aims to counter negative perceptions and showcase commitment to sustainability and position Malaysia as a leader in wildlife protection.
Global Cooperation: It seeks to strengthen ties with major palm oil importers like China, India, and the EU through conservation partnerships.
Criticisms:
Habitat Concerns: Critics argue real conservation requires protecting habitats, not just symbolic actions.
Comparisons to Panda Diplomacy: Malaysia’s effort lacks the infrastructure and commitment seen in China’s panda conservation.
PYQ:
[2021] With reference to ‘palm oil’, consider the following statements :
1. The palm oil tree is native to Southeast Asia.
2. The palm oil is a raw material for some industries producing lipstick and perfumes.
3. The palm oil can be used to produce biodiesel.
The Central government asked the Union Public Service Commission (UPSC) on Tuesday, August 20, to cancel an advertisement from three days earlier that called for applications to fill senior government positions through lateral recruitment.
What is ‘Lateral Entry’ into the Bureaucracy?
Definition: Lateral entry refers to the recruitment of personnel from outside the traditional civil services into senior and middle-level positions in the central government. These entrants come from various backgrounds, including state/UT governments, public sector undertakings (PSUs), statutory organizations, research institutes, universities, and the private sector.
Objective: The idea is to bring in individuals with domain expertise and specialized knowledge to enhance the efficiency and effectiveness of governance. These individuals are usually appointed on contracts of three years, which can be extended to a total of five years.
What are the Positions Open for Lateral Entry?
Positions Advertised: Lateral entry initially focused on Joint Secretary-level positions, which are high-ranking roles within a Department. Over time, positions for Director and Deputy Secretary levels were also opened.
Roles and Responsibilities:
Joint Secretary: Third-highest rank in a Department, responsible for decision-making and administrative head of a wing within the Department.
Director/Deputy Secretary: Middle-level officials, performing roles similar to Joint Secretaries in most ministries.
What was the Union Government’s Logic Behind Introducing Lateral Entries?
Rationale: The government introduced lateral recruitment to bring in fresh talent and specialized skills that may not be available within the traditional civil services.
NITI Aayog’s Recommendation: The policy was recommended in 2017 by NITI Aayog in its three-year Action Agenda and by the Sectoral Group of Secretaries (SGoS) on Governance.
How Many People Have Been Appointed via Lateral Recruitment So Far?
First Round (2018): The first round attracted 6,077 applications for Joint Secretary-level positions. Nine individuals were eventually selected and appointed in 2019.
Subsequent Rounds: Additional rounds of recruitment occurred in 2021 and May 2023. As of August 2024, a total of 63 appointments have been made through lateral entry, with 57 lateral entrants currently holding positions in various Ministries/Departments.
What is the Criticism of Lateral Entry Recruitment?
Lack of Reservations: A significant criticism of lateral recruitment is the absence of quotas for Scheduled Castes (SC), Scheduled Tribes (ST), and Other Backward Classes (OBC).
Promotion Concerns: Critics like Mayawati have pointed out that lateral entry deprives lower-level employees in the civil services of promotion opportunities, which would otherwise be available through a merit-based system.
Way forward:
Incorporate Inclusive Quota Provisions: To address the criticism regarding the absence of reservations, the government could consider introducing a reservation policy for Scheduled Castes (SC), Scheduled Tribes (ST), and Other Backward Classes (OBC) in lateral entry recruitment.
Establish a Transparent and Merit-Based Selection Process: To ensure the credibility and effectiveness of lateral recruitment, the government should enhance transparency in the selection process. This could involve clearly defined eligibility criteria, objective assessment methods, and regular monitoring of the performance of lateral entrants.
Mains PYQ:
Q Has the Cadre-based Civil Services Organization been the cause of slow in India? Critically examine. (UPSC IAS/2014)
From UPSC perspective, the following things are important :
Prelims level: Biosimilar;
Mains level: Outdated Biosimilar Guidelines in India;
Why in the News?
The government has introduced two import-based initiatives to meet domestic needs, which could potentially dampen the growth of the domestic industry.
New medicines are generally under patent protection, preventing Indian companies from producing affordable generics/biosimilars.
Impact of two initiatives on Domestic Industry:
Global Tendering for 120 Medicines: The Department of Expenditure (DoE) allowed the Ministry of Health to buy 120 medicines, including popular anti-diabetes and anti-cancer drugs, through global tenders for government programs. This decision, which specifies certain brands for over 40 of these medicines, could increase the monopoly of foreign companies in India.
Customs Duty Removal on Cancer Medicines: The 2024-25 Union Budget proposed removing the 10-12% customs duty on three cancer medicines marketed by AstraZeneca. While intended to reduce prices, this measure is unlikely to significantly lower costs and may instead increase reliance on imports, further disadvantaging domestic producers.
Status of Indian Pharma
India is a leading manufacturer of vaccines, accounting for 60% of global production.
India supplies 70% of vaccines used by the WHO.
India is a major exporter of generic drugs, accounting for 20% of global exports.
The industry is expected to grow to over $130 billion by 2030.
What are Biosimilar guidelines?
Biosimilar guidelines in India are regulatory frameworks established by the Central Drugs Standard Control Organization (CDSCO) and theDepartment of Biotechnology (DBT) to govern the development, approval, and marketing of biosimilars.
Biosimilars are biologic medical products that are highly similar to an already approved original biologic (known as the reference product), with no clinically meaningful differences in terms of safety, purity, and potency.
Status Biosimilars:
Significant Market Size: The biosimilar market in India is valued at approximately $2.2 billion, and it is projected to reach $40 billion by 2030. This growth is driven by the expiration of patents for several key biologics, which opens the door for biosimilar development.
Product Approvals: As of now, over 70 biosimilars have been approved in India, covering a range of therapeutic areas, including oncology, diabetes, and autoimmune diseases. Notable examples include:
Adalimumab (for rheumatoid arthritis)
Trastuzumab (for breast cancer)
Filgrastim (for neutropenia)
Insulin glargine (for diabetes)
Outdated Biosimilar Guidelines in India:
Obsolete and Resource-Intensive:
India’s biosimilar guidelines are outdated, requiring mandatory animal studies, which are no longer necessary in developed countries like the U.S. and EU with stringent regulatory standards.
The guidelines also mandate clinical trials, while WHO and U.K. guidelines treat clinical trials as an exception rather than a rule.
Barrier for Domestic Producers:
The stringent requirements for animal studies and mandatory clinical trials create significant barriers for Indian producers, making it difficult for them to compete with their global counterparts.
Impact on Patient Access:
According to the International Generic and Biosimilar Medicines Association, eliminating these duplicative requirements could lead to significant savings in time and resources, ultimately improving patient access to affordable biosimilars.
Way forward:
Update Regulatory Guidelines: Modernize India’s biosimilar guidelines by removing unnecessary requirements like mandatory animal studies and clinical trials, aligning them with global standards to reduce barriers for domestic producers.
Support Local Production: Utilize provisions in the Patents Act to promote domestic manufacturing of affordable medicines, reducing reliance on imports and strengthening the local pharmaceutical industry.
From UPSC perspective, the following things are important :
Prelims level: Tera Hertz (THz) Spectrum
Why in the News?
The Telecom Regulatory Authority of India (TRAI) released its recommendations on the Tera Hertz Spectrum.
About Tera Hertz (THz) Spectrum
The THz Spectrum refers to a range of electromagnetic waves with frequencies between 100 GHz (gigahertz) and 10 THz (terahertz).
This spectrum lies betweenmicrowaves and infrared light.
It is known as the “THz gap” because it has been less explored compared to other parts of the electromagnetic spectrum.
Key Features:
Unique Properties: THz waves can pass through many materials like clothing, paper, and wood but are absorbed by water and metals.
Applications: Used for advanced technologies like imaging, communications, and spectroscopy.
Potential Uses: Security scanning, medical imaging, and high-speed wireless communication.
Impact of recent recommendation:
THEA will encourage innovation in Tera Hertz technologies, supporting the ‘Make in India’ initiative.
The opening of specific frequency bands will boost the development and deployment of next-generation wireless technologies and automotive safety systems in India.
PYQ:
[2020] With reference to Visible Light Communication (VLC) technology, which of the following statements are correct?
1. VLC uses electromagnetic spectrum wavelengths 375 to 780 nm.
2. VLC is known as long-range optical wireless communication.
3. VLC can transmit large amounts of data faster than Bluetooth.
4. VLC has no electromagnetic interference.
Select the correct answer using the code given below:
From UPSC perspective, the following things are important :
Prelims level: Global Finance Central Banker Report Cards, 2024
Why in the News?
The Reserve Bank of India (RBI) Governor has been awarded an “A+” rating for the second consecutive year in the Global Finance Central Banker Report Cards 2024.
About the Global Finance Central Banker Report Cards
The Central Banker Report Cards are published annually by Global Finance, a magazine that has been grading central bank governors since 1994.
The report grades the central bank governors of nearly 100 countries, territories, and districts, including major institutions like the European Union, the Eastern Caribbean Central Bank, the Bank of Central African States, and the Central Bank of West African States.
Grading Scale:
The ratings range from “A+” for excellent performance to “F” for outright failure.
The grades assess success in key areas such as inflation control, economic growth, currency stability, and interest rate management.
Significance
This recognition highlights his exceptional performance in managing India’s monetary policy, particularly in areas such as inflation control, economic growth, currency stability, and interest rate management.
PYQ:
[2016] ‘Global Financial Stability Report’ is released by which organisation?
(a) European Central Bank
(b) International Monetary Fund
(c) International Bank for Reconstruction and Development
(d) Organisation for Economic Co-operation and Development
From UPSC perspective, the following things are important :
Prelims level: Polio and its eradication
Why in the News?
The World Health Organization (WHO) is investigating a suspected new strain of polio in a two-year-old child from Tikrikilla, Meghalaya.
What is Vaccine-Derived Polio?
The Oral Polio Vaccine (OPV) contains a weakened form of the poliovirus that activates an immune response in the body.
The vaccine-virus is excreted after vaccination and can circulate in the environment.
In rare cases, if the population is under-immunized, the excreted virus can mutate over time and revert to a form capable of causing paralysis.
This mutated virus is known as circulating vaccine-derived poliovirus (cVDPV).
About Polio:
Details
Nature of Disease
Crippling and potentially deadly viral infectious disease affecting the nervous system.
Types of Poliovirus
– WPV1 (Wild Poliovirus type 1)
– WPV2 (Wild Poliovirus type 2, eradicated globally)
– WPV3 (Wild Poliovirus type 3, eradicated globally)
Current Status
WPV1 remains in circulation in Afghanistan and Pakistan.
Transmission
Primarily through the faecal-oral route or contaminated water/food.
Affected Population
Largely affects children under 5 years of age.
Impact
Virus multiplies in the intestine, may invade the nervous system, causing paralysis.
Prevention
– No Cure: Preventable through immunization.
– Vaccines:
– OPV: Oral Polio Vaccine given at birth, with doses at 6, 10, 14 weeks, and a booster at 16-24 months.
– IPV: Injectable Polio Vaccine given with the 3rd dose of DPT under UIP.
India’s Status
Pulse Polio Immunization Initiative (1995)
Declaredpolio-free by WHO in 2014, with the last wild poliovirus case reported in 2011.
PYQ:
[2016] ‘Mission Indradhanush’ launched by the Government of India pertains to:
(a) immunization of children and pregnant women
(b) construction of smart cities across the country
(c) India’s own search for the Earth-like planets in outer space
From UPSC perspective, the following things are important :
Mains level: Importance of Malaysia for India;
Why in the News?
India and Malaysia have elevated their relationship to a ‘Comprehensive Strategic Partnership’ following talks between Prime Ministers Modi and Ibrahim, aiming to overcome past tensions.
What is a Comprehensive Strategic Partnership (CSP)?
The Comprehensive Strategic Partnership (CSP) represents a deepened level of engagement between two nations, encompassing a broad spectrum of areas such as political, economic, cultural, and security cooperation.
This partnership reflects a commitment to working closely across these domains to achieve mutual goals.
Upgradation of ties between India and Malaysia:
The recent upgrade includes agreements and MoUs in workers’ mobility, digital technology, culture, tourism, sports, and education.
India has also agreed to support Malaysia’s bid to join the BRICS grouping, which the Malaysian Prime Minister has been advocating for.
The leaders discussed new areas of cooperation, including semiconductors, fintech, defence industry, artificial intelligence (AI), and quantum technologies.
A special allocation of 200,000 metric tonnes of white rice was granted by India to Malaysia in response to Malaysia’s request, reflecting India’s role in Malaysia’s food security.
Bilateral Friction between India and Malaysia:
Citizenship Amendment Act (CAA): During the Kuala Lumpur Summit in December 2019, Malaysian PM Mahathir Mohamad criticized India’s CAA, which provides a pathway to citizenship for non-Muslim refugees from Afghanistan, Bangladesh, and Pakistan.
Reorganisation of Jammu and Kashmir: Mahathir Mohamad also voiced strong criticism regarding India’s reorganization of Jammu and Kashmir, particularly after the revocation of its special status in August 2019.
Extradition of Zakir Naik: India’s repeated requests for the extradition of Zakir Naik, wanted on charges of hate speech and money laundering, have been denied by Malaysia, citing insufficient evidence.
COVID-19 Pandemic: During the pandemic, hundreds of Malaysians were detained in India due to the lockdown, further adding to tensions.
Way forward:
Enhance Diplomatic Engagement: Continue regular high-level dialogues to resolve sensitive issues and foster mutual trust, focusing on joint working groups for contentious matters like extradition and human rights.
Expand Strategic and Economic Collaboration: Prioritize joint ventures and research in emerging sectors such as fintech, AI, and quantum technologies to strengthen economic ties and minimize political friction.
From UPSC perspective, the following things are important :
Mains level: Challenges due to Low wages and short-term skill programs;
Why in the News?
The ambitious ₹2 lakh crore employment package aims to create 4.1 crore jobs, but evidence shows low wages and short-term skill programs hinder long-term sustainability.
Low wages and short-term skill programs hinder long-term sustainability:
Low Wages Lead to Economic Insecurity: Low wages create economic insecurity for workers, making it difficult for them to meet basic needs. For instance, in the garment industry, there is a 48.5% gap between minimum wages and living wages in major garment-producing countries.
Short-Term Skill Programs Fail to Enhance Employability: Many short-term skill programs do not provide the depth of training needed for long-term employability. In India, for example, 75% of technical graduates and 90% of other graduates are considered unemployable, primarily due to a lack of practical skills and experience that employers seek.
Stagnation of Workforce Productivity: When workers are paid low wages, there is little incentive for them to enhance their skills or productivity. This stagnation is detrimental to both individual career growth and overall economic development.
Lack of Investment in Long-Term Skill Development: Low wages often correlate with limited investment in employee training and development.This is evident in the fact that only 15% of those trained under the Pradhan Mantri Kaushal Vikas Yojana (PMKVY) found jobs, indicating that short-term training initiatives are not effectively translating into sustainable employment outcomes.
Perpetuation of Poverty and Inequality: The combination of low wages and inadequate skill development contributes to the perpetuation of poverty and inequality. With 42% of the global workforce in vulnerable employment.
12-point policy initiatives for sustainable mass employment:
Identify the skill need: Begin from below through decentralized community action to identify skilling needs. Create a register of those wanting employment/self-employment and a plan for every youth in partnership with professionals at the cluster level.
Initiative at the local level: Converge initiatives for education, health, skills, nutrition, livelihoods, and employment at the local government level with women’s collectives to ensure community accountability and effective outcomes.
Vocational programmes: Introduce need-based vocational courses/certificate programmes alongside undergraduate programmes in every college to improve employability.
Healthcare at international benchmark: Standardize nursing and allied health-care professional courses according to international benchmarks to meet the demand for skilled professionals.
Women security: Create community cadres of caregivers to run crèches universally so that women can work without fear.
Invest in skill development: Invest in ITIs, and polytechnics as hubs in skill development for feeder schools with a focus on States/districts with the least institutional structure for vocational education.
Startup skills in high school: Introduce enterprise and start-up skills through professionals in high schools to impart finishing skills to students.
Apprenticeship program in Industry: Have a co-sharing model of apprenticeships (combine practical training in a job with study) with the industry on scale to ensure the industry has a stake in the apprenticeship program.
Absorption of youth at the workplace: Apprenticeships on the scale can facilitate the absorption of youth in the workplace, with the government’s condition for employer subsidies being wages of dignity on successful completion of the apprenticeship.
Capital oan for women: Streamline working capital loans for women-led enterprises/first-generation enterprises to enable them to go to scale.
Skill accreditation programme: Start a universal skill accreditation programme for skill-providing institutions, with candidates co-sponsored by the state and employers.
Majority of fund in water scares block: Use 70% funds under MGNREGA in 2,500 water-scarce blocks and blocks with high deprivation, with a thrust on the poorest 20 families and a focus on skills for higher productivity.
Way forward:
Strengthen Industry-Academia Linkages: Enhance collaboration between educational institutions, industry, and vocational training centers to align curricula with industry needs, ensuring employability through internships, apprenticeships, and job placements.
Focus on Inclusive Skill Development: Prioritize investment in underdeveloped regions and marginalized groups by expanding access to quality education, vocational training, and entrepreneurship opportunities, especially for women and youth, to bridge the skill gap and promote economic inclusion.
From UPSC perspective, the following things are important :
Prelims level: Status of Cancer in India;
Mains level: Limitation of Multi-Cancer Early Detection (MCED) Test;
Why in the News?
A multi-cancer early detection test can identify circulating tumour DNA or circulating tumour cells at an early stage, allowing for more effective treatment.
Status of Cancer:
Cancer’s Impact in India: Cancer accounts for 18% of deaths from noncommunicable diseases in India, making it the second leading cause of mortality. In 2022, there were approximately 1.46 million new cancer cases, with projections indicating a 12% increase by 2025.
Common Cancers as per GLOBOCAN: Among women, the most prevalent cancers are breast, cervical, ovarian, and colorectal.
For men, lung, esophageal, colorectal, and stomach cancers are the most common.
Survival Rates and Detection: Late detection of cancer significantly reduces survival rates and increases treatment costs. In contrast, early detection through screening improves treatment outcomes and quality of life.
Countries are aligning with the United Nations’ Sustainable Development Goals 3 to enhance early cancer detection.
Limited screening: As per NHFS, screening is limited in India which is primarily to cervical, breast, and oral cancers, with only 0.2-2% of the population having undergone any form of screening.
What is a Multi-Cancer Early Detection (MCED) Test?
A multi-cancer early detection (MCED) test is a new type of blood test that can screen for multiple types of cancer simultaneously. These tests look for cancer signals, such as circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), released by cancerous cells into the bloodstream at early stages.
Role of Blood-based tests in the detection of cancer:
Early Detection of Multiple Cancer Types: Blood tests, particularly multi-cancer early detection (MCED) tests, can identify cancer signals from over 50 different types of cancer, including those that currently lack effective screening methods.
For example, a recent study demonstrated that a new blood test could detect 93% of stage 1 cancers in men and 84% in women by analyzing protein biomarkers.
Non-Invasive and Accessible Screening: Blood tests are non-invasive and can be performed with a simple blood draw, making them more accessible compared to traditional screening methods like colonoscopies or imaging tests. This ease of use encourages more individuals to participate in screening.
Limitation of blood test in the detection of Cancer:
Lack of Proven Mortality Benefit: It is still unclear whether detecting cancers earlier with MCED tests will actually reduce cancer deaths. More research is needed to determine if earlier treatment based on MCED results improves outcomes compared to waiting for symptoms to develop.
Regulatory Challenges: MCED tests are not yet approved by regulatory bodies like the U.S. FDA or India’s CDSCO because of not undergone rigorous premarket review to prove they benefit patients.
False Positives: One significant risk is false positive results, where the test indicates cancer when none is present. When multiple tests are used for screening, the false positive rate can be as high as 50%.
Way forward:
Strengthening Screening Infrastructure and Research: India should invest in expanding its cancer screening infrastructure, ensuring that more types of cancer are included beyond cervical, breast, and oral cancers.
Public Awareness and Regulatory Preparedness: Increasing public awareness about the importance of early cancer detection is crucial. At the same time, regulatory bodies like CDSCO should establish clear guidelines and frameworks for the evaluation, approval, and monitoring of MCED tests.
From UPSC perspective, the following things are important :
Prelims level: JUICE Mission
Why in the News?
European scientists are preparing to execute a first-of-its-kind ‘Double Slingshot’ orbital maneuver to guide the JUICE probe towards Jupiter using a double slingshot technique.
About JUICE Mission:
Details
Launch
By European Space Agency (ESA) on April 14, 2023, Ariane 5 rocket
To study Jupiter’s Moons
Aim
Investigating the potential for life on Jupiter’s moons and understanding the Jovian system
Mission Duration
Approximately 12 years
Expected arrival at Jupiter in July 2031
Primary Objectives
Ganymede Exploration: Study its surface, subsurface, magnetic field, and potential subsurface ocean to assess habitability.
Europa Exploration: Investigate the surface, subsurface, and potential ocean beneath the ice; analyze interactions with Jupiter’s magnetosphere to assess its potential to support life.
Callisto Exploration: Study its surface, geological diversity, and possible subsurface ocean; understand its history of impacts and tectonic activity.
Jupiter System Exploration: Analyze Jupiter’s atmosphere, magnetosphere, and their interactions with the moons; study the dynamics of the magnetosphere and its influence on the surrounding environment.
Key Instruments
JANUS: Jovis, Amorum ac Natorum Undique Scrutator (Optical Camera)
RIME: Radar for Icy Moons Exploration
J-MAG: JUICE Magnetometer
MAJIS: Moons and Jupiter Imaging Spectrometer
Significance
First interplanetary spacecraft to the outer Solar System planets not launched by the United States
First mission set to orbit a moon other than Earth’s Moon
What is theDouble Slingshot Maneuver?
The JUICE probe will first use the moon’s gravity to set itself on the correct trajectory towards Earth.
Immediately after, it will useEarth’s gravity to slow down and redirect towards Venus and, eventually, Jupiter.
Significance of the Gravity Assist
This technique, used for decades in space exploration, involves using a planet or moon’s gravity to alter the speed or direction of a spacecraft.
It is unique as it involves back-to-back gravity assists using both the moon and Earth’s gravity, which has never been attempted before.
PYQ:
[2020] The experiment will employ a trio of spacecraft flying in formation in the shape of an equilateral triangle that has sides one million kilometres long, with lasers shining between the craft.” The experiment in question refers to
From UPSC perspective, the following things are important :
Prelims level: Schedule IV of the Wild Life (Protection) Act, 1972
Why in the News?
Many individuals, organizations, and zoos in India currently possess living specimens of exotic animal species listed under Schedule IV of the Wild Life (Protection) Act, 1972.
These exotic species must be reported and registered as mandated by the Ministry of Environment, Forest and Climate Change in the PARIVESH 2.0 Portal.
Legal Framework for Reporting of Animals in Possession
The Living Animal Species (Reporting and Registration) Rules, 2024, were notified under Section 49 M of the Wild Life (Protection) Act via a Gazette Notification on February 28, 2024.
Who Must Register: Any person or entity in possession of a living specimen of species listed in Schedule IV of the Wild Life (Protection) Act, 1972.
Failure to report and register these species within the stipulated time frame may result in penal actions.
About Schedule IV of the WPA
Details
Protection Level
Provides legal protection to species, prohibiting their hunting, capture, or trade. Protection is less stringent compared to Schedules I & II.
Offenses and Penalties
Violations can lead to fines and imprisonment, but penalties are generally less severe than those for species in higher schedules.
New Amendment (2022)
The Wildlife (Protection) Amendment Act, 2022, inserted a new Schedule IV for specimens listed in the CITES Appendices.
Examples of Species
Flamingos, Hares, Falcons, Kingfishers, Magpie, and Horseshoe Crabs.
Purpose
Ensures legal protection to prevent exploitation and population decline of species that are not critically endangered but still need protection.
General Protection Role
Plays an important role in broader conservation efforts, offering safeguards to a wider range of species in India.
PYQ:
[2020] If a particular plant species is placed under Schedule VI of The Wildlife Protection Act, 1972, what is the implication?
(a) A licence in required to cultivate that plant.
(b) Such a plant cannot be cultivated under any circumstances.
(c) It is a Genetically Modified crop plant.
(d) Such a plant is invasive and harmful to the ecosystem.
From UPSC perspective, the following things are important :
Prelims level: Quantum Non-Locality
Why in the News?
A recent study published in Physical Review Letters by Indian researchers has revealed that a universal standard for measuring quantum non-locality is impossible.
What is Quantum Nonlocality?
Quantum Nonlocality is a mysterious connection between distant objects that challenges the classical idea of local realism, where no faster-than-light communication is allowed.
It’s crucial for technologies like secure communication, random number generation, and cryptographic key creation.
Easy Explanation:
Imagine two particles that are created together and then move far apart, even to opposite ends of the universe.
In classical physics, any effect on one particle would need a signal to travel to the other, taking time.
But in quantum physics, Quantum Nonlocality means these particles are instantly connected, affecting each other no matter the distance, as if linked by an invisible thread that works faster than light.
Historical Background: Bell’s Theorem (1964)
Physicist John Stewart Bell introduced a theorem that challenged the classical idea of ‘local realism’ in quantum systems.
Local Realism: In classical physics, objects are believed to have definite properties independent of observation and are only influenced by their immediate surroundings.
Quantum Challenge: Bell demonstrated that in quantum systems with multiple, distant parts, correlations appear that cannot be explained by local realism.
Bell’s theorem was confirmed through experiments, leading to the recognition of quantum nonlocality, which was honored with the 2022 Physics Nobel Prize.
Recent Research and Findings
The research demonstrates that a universal standard for measuring and comparing quantum nonlocality is impossible.
It shows that the nature of nonlocality varies based on the type of correlation, with infinite unique points on the correlation boundary.
There is no single, universal resource in the realm of quantum nonlocality; instead, each nonlocal resource is unique, capable of performing specific tasks that others cannot.
This observation plays a key role in secure communication, random number certification, and cryptographic key generation.
PYQ:
[2022] Which one of the following is the context in which the term “qubit” is mentioned?
From UPSC perspective, the following things are important :
Prelims level: Hayflick Limit
Why in the News?
Leonard Hayflick, the renowned biomedical researcher who made a discovery about the limits of cell division in somatic cells (Hayflick Limit) has passed away at 98.
What is the Hayflick Limit?
In the early 1960s, Hayflick discovered that somatic (non-reproductive) cells have a finite number of divisions, typically between 40-60 times.
This phenomenon, the ‘Hayflick limit’ suggests that aging occurs because cells eventually stop dividing.
This leads to the accumulation of senescent cells that contribute to the aging process.
The “ultimate Hayflick limit” for humans is estimated to be around 125 years.
Beyond this, no amount of lifestyle changes or medical interventions can extend the human lifespan.
Hayflick’s discovery has been applied to cells from various animals, revealing different Hayflick limits based on species’ lifespans.
Ex. Galapagos turtles, have cells that can divide approximately 110 times, whereas laboratory mice have a much lower limit of around 15 divisions.
Broader Implications and Research
Hayflick’s discovery led to the discovery of telomeres in the 1970s.
Telomeres are protective DNA sequences at the ends of chromosomes, which shorten with each cell division.
When telomeres reach a critical length, cell division stops, which correlates with the Hayflick limit.
In the 1980s, scientists discovered telomerase, a protein capable of replenishing telomeres, which is naturally active in cancer cells, allowing them to bypass the Hayflick limit.
PYQ:
[2011] Regular intake of fresh fruits and vegetables is recommended in the diet since they are a good source of antioxidants. How do antioxidants help a person maintain health and promote longevity?
(a) They activate the enzymes necessary for vitamin synthesis in the body and help prevent vitamin deficiency
(b) They prevent excessive oxidation of carbohydrates, fats and proteins in the body and help avoid unnecessary wastage of energy
(c) They neutralize the free radicals produced in the body during metabolism
(d) They activate certain genes in the cells of the body and help delay the ageing process
From UPSC perspective, the following things are important :
Prelims level: Waterspout
Why in the News?
A yacht sank off the coast of Sicily, Italy after being hit by a Waterspout.
What are Waterspouts?
A waterspout is a rotating column of air and mist over a water body.
It is a weaker relative of tornadoes and typically lasts for about five minutes, although it can occasionally last up to 10 minutes.
Size and Strength:
Average diameter: Around 165 feet.
Wind speeds: Can reach up to 100 km/hr.
Waterspouts are more common in tropical waters but can form anywhere with high humidity and relatively warm water temperatures compared to the overlying air.
Types of Waterspouts:
Tornadic Waterspouts
These are actual tornadoes that either form over water or move from land to water.
They are associated with severe thunderstorms and can be accompanied by high winds, large hail, and dangerous lightning.
Fair-Weather Waterspouts:
These are more common and form only over water during fair weather.
They are generally smaller and less dangerous than tornadic waterspouts.
PYQ:
[2020] Consider the following statements:
1. Jet streams occur in the Northern Hemisphere only.
2. Only some cyclones develop an eye.
3. The temperature inside the eye of a cyclone is nearly 10ºC lesser than that of the surroundings.
Which of the statements given above is/are correct?
From UPSC perspective, the following things are important :
Prelims level: Viksit Bharat@2047;
Mains level: Economic and Military challenges for India;
Why in the News?
India’s 78th Independence Day is a time to reflect on our significant successes and setbacks. We should learn from both to make quicker progress towards the Prime Minister’s vision of a Viksit Bharat@2047 by 2047.
Key Aspects of Viksit Bharat@2047
Economic Growth: The vision aims to elevate India to the status of the world’s third-largest economy and strive for a $30 trillion economy by 2047.
Environmental Sustainability: Viksit Bharat aims to preserve biodiversity and mitigate climate change impacts through restoration and conservation efforts.
Social Progress: The initiative seeks to build an inclusive society that respects cultural diversity and ensures the dignity and well-being of all citizens.
Good Governance: Effective governance is a cornerstone of the Viksit Bharat vision, focusing on accountability, transparency, and sound policies that are responsive to the needs of the people.
Youth Engagement: Recognizing the potential of India’s youth, the government has launched initiatives like the “Voice of Youth” portal to encourage young people to contribute ideas for achieving the goals of Viksit Bharat.
Economic Challenges
Weak Domestic Demand: Stagnant or declining demand for goods and services due to low-income growth, high inflation, unemployment, and the impact of the Covid-19 pandemic.
High Unemployment: Despite rapid growth, unemployment remains a serious issue, worsened by the pandemic. The unemployment rate in India rose to 8.1 per cent in April 2024 from 7.4 per cent in March 2024, according to CMIE’s Consumer Pyramids Household Survey.
Poor Infrastructure: India lacks adequate infrastructure like roads, railways, ports, power, water and sanitation, hampering economic development. The infrastructure gap is estimated at around $1.5 trillion.
Balance of Payments Deterioration: India runs a persistent current account deficit, with imports exceeding exports. Exports and imports decreased by 6.59% and 3.63% respectively in 2022.
High Private Debt Levels: India has witnessed a significant rise in debt levels in recent years.
According to the Reserve Bank of India (RBI), the total non-financial sector debt reached 167% of GDP in March 2020, up from 151% in March 2016.
Household debt in India rose to 40.10% of GDP in the fourth quarter of 2023, up from 39% in the previous quarter.
Military Challenges
Securing Borders: Despite conflicts with Pakistan and China, India has reasonably managed border security. However, the rapid rise of China poses economic and military challenges.
China’s Growing Influence: Almost all of India’s neighbours are moving closer to China, necessitating better policy and diplomacy to secure India’s interests and ensure regional stability.
Military Modernization and Resource Allocation: India’s dependence on foreign arms imports, despite efforts to promote self-reliance through initiatives like “Make in India,” highlights the need for a robust domestic defense industry.
The country has been the largest arms importer from 2018 to 2022, indicating ongoing challenges in achieving military self-sufficiency
Suggestive measures: (Way forward)
Agricultural Reforms: Investment in agricultural research and development, irrigation, and land-lease markets is vital. Building value chains for perishables can enhance food security and adapt to climate challenges.
Nutritional Security: Transitioning from mere food security to nutritional security is crucial, addressing issues like child malnutrition, which affects 35% of children under five.
Support for Farmers: Implementing subsidies for pulses and other sustainable crops can encourage healthier diets and environmental benefits. The government should provide financial incentives to farmers to shift from water-intensive crops to pulses.
Infrastructure Development: Continued investment in infrastructure, including transportation and digital connectivity, is essential for economic growth and improving citizens’ quality of life.
Education and Skill Development: Reforms in education to prioritize skill development and innovation are necessary to prepare the workforce for emerging industries and ensure inclusive growth.
Healthcare Initiatives: Expanding access to affordable healthcare services nationwide is critical for enhancing public health and productivity.
Mains PYQ:
Q Foreign Direct Investment (FDI) in the defence sector is now set to be liberalized: What influence this is expected to have on Indian defence and economy in the short and long run? (UPSC IAS/2016)
