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Type: Prelims Only

  • Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

    Risk of mucormycosis in Covid-19 patients

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Mucormycosis

    Mains level: Paper 2- Mucormycosis infection risk in Covid-19 patients

    About mucormycosis

    • Mucormycosis is a fungal infection that has a high mortality rate of 50 per cent.
    • An increasing number of Covid-19 patients have been developing this infection while still at the hospital or after discharge.
    • The disease often manifests in the skin and also affects the lungs and the brain.
    • Some of the common symptoms include sinusitis, blackish nasal discharge, facial pain, headaches, and pain around the eyes.

    Who is at risk

    • Patients who have been hospitalised for Covid-19 and particularly those who require oxygen therapy during Covid-19 illness are at a much higher risk of mucormycosis.
    • However, there are some cases of mucormycosis in patients with asymptomatic Covid-19 infection.
    • Before the pandemic, patients with uncontrolled diabetes were at a higher risk of mucormycosis.
    • The risk of mucormycosis rises for these patients for two reasons.
    • First is that Covid-19 further impairs their immune system.
    • Second, they are given corticosteroids for their treatment it leads to a rise in their blood sugar level thus increasing their risk of mucormycosis.

    Treatment

    • Today, we have a number of drugs and anti-fungal medicines that can treat mucormycosis.
    • These are given by IV or taken orally.
    • Surgery is needed to remove the affected dead tissues along with antifungal therapy.

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  • ISRO Missions and Discoveries

    NASA’s OSIRIS-REx begins journey back from asteroid

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Asteroid Bennu

    Mains level: Paper 3- OSIRIS-REx starts journey back to the earth

    On May 11, NASA’s Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS-REx) spacecraft will depart asteroid Bennu, and start its two-year-long journey back to Earth.

    About OSIRIS-REx

    • OSIRIS-REx is NASA’s first mission to visit a near-Earth asteroid, survey its surface and collect a sample from it.
    • The mission was launched in 2016, it reached its target in 2018 and since then, the spacecraft has been trying to match the velocity of the asteroid using small rocket thrusters.
    • It also utilised this time to survey the surface and identify potential sites to take samples.
    • In October 2020, the spacecraft briefly touched asteroid Bennu, from where it collected samples of dust and pebbles. 
    • Once the surface was disturbed, the spacecraft’s robotic arm captured some samples.
    • The spacecraft’s engineers have also confirmed that shortly after the spacecraft made contact with the surface, it fired its thrusters and “safely backed away from Bennu”.

    About Bennu

    • Bennu is considered to be an ancient asteroid that has not gone through a lot of composition-altering change through billions of years, which means that below its surface lie chemicals and rocks from the birth of the solar system.
    • Around 20-40 percent of Bennu’s interior is empty space and scientists believe that it was formed in the first 10 million years of the solar system’s creation, implying that it is roughly 4.5 billion years old.
    • Bennu is a B-type asteroid, implying that it contains significant amounts of carbon and various other minerals.
    • Because of its high carbon content, the asteroid reflects about four percent of the light that hits it, which is very low when compared with a planet.
    • Bennu is named after an Egyptian deity.
    • The asteroid was discovered by a team from the NASA-funded Lincoln Near-Earth Asteroid Research team in 1999.

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  • Pharma Sector – Drug Pricing, NPPA, FDC, Generics, etc.

    What is 2-deoxy-D-glucose (2-DG) and is it effective against Covid?

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: 2-DG

    Mains level: Paper 3- Drug developed by DRDO approved for Covid treatment

    About the drug

    • DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI).
    •  2-DG halts the spread of COVID-19 inside the body cells.
    • Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence.
    • In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.
    • A significantly favourable trend (2.5 days difference) was seen in terms of the median time to achieving normalisation of specific vital signs parameters when compared to SoC.

    How 2-DG reduces dependence on oxygen

    • The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production.
    • The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen.

     

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  • Hottest planet in the known universe discovered

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Hottest known planet

    Mains level: Paper 3-Hottest known planet discoverd

    About the plane

    • TOI-1431b, also known as MASCARA-5b, was found 490 light-years from Earth and could be the hottest planet in the known universe.
    • Researchers at the University of Southern Queensland’s Centre for Astrophysics in Toowoomba led the global team that made the discovery.
    • NASA’s Training Exoplanet Survey Satellite first flagged TOI-1431b as a possible planet in late 2019.
    • Dayside temperature reaches approximately 2700 degrees celcius and nightside temperature approaches approximately 2300 degrees celcius – no life could survive in its atmosphere.
    • This temperature is significantly greater than the melting point of most metals, many of which will turn to liquid at under 2000 degrees celcius.
    • Titanium melts at 1670 degrees, platinum at 1770 degrees, and stainless steel at between 1375 and 1530 degrees.

    Planet with a retrograde orbit

    • These types of planets, known as ultra-hot Jupiters, are rarely discovered but this particular one is even more unusual due to its retrograde orbit.
    • In our Solar System, all the planets orbit in the same direction that the Sun rotates and they’re all along the same plane.
    • This new planet’s orbit is tilted so much that it is actually going in the opposite direction to the rotation of its host star.

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  • Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

    Understanding the Ct value in a Covid-19 test

    ExplainedPrelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: RT-PCR Test

    Mains level: Paper 2- Ct value in RT-PCR test

    Recently, the Maharashtra government sought clarity from the Indian Council of Medical Research (ICMR) on the threshold Ct value to treat a person Covid-negative.

    What is Ct value

    • Short for cycle threshold, Ct is a value that emerges during RT-PCR tests.
    • In an RT-PCR test, RNA is extracted from the swab collected from the patient.
    • It is then converted into DNA, which is then amplified.
    • Amplification refers to the process of creating multiple copies of the genetic material — in this case, DNA.
    • Amplification takes place through a series of cycles — one copy becomes two, two becomes four, and so on.
    • Put simply, the Ct value refers to the number of cycles after which the virus can be detected.
    • The lower the Ct value, the higher the viral load — because the virus has been spotted after fewer cycles.

    Why Ct value is important

    • According to the ICMR, a patient is considered Covid-positive if the Ct value is below 35.
    • If the benchmark were to be lowered to 24 — the value mentioned in Maharashtra’s letter — it would mean that Ct values in the range 25-34 would not be considered positive.
    • A benchmark of 35, therefore, means that more patients would be considered positive than we would get if the benchmark were 24.
    • The ICMR has said lowering Ct threshold parameter may lead to missing several infectious persons.

    Does Ct score indicate the severity of disease

    • A small study published in the Indian Journal of Medical Microbiology in January this year found that there was no correlation between Ct values and severity of disease or mortality in patients with Covid-19 disease.
    • It found that the time since the onset of symptoms has a stronger relationship with Ct values as compared to the severity of the disease.
    • The Ct value tells us about the viral load in the throat and not in the lungs.
    • The Ct value does not correlate with severity – only with infectivity.

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  • Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

    Emergency use nod for Virafin

    Prelims Only | Governance | Mains Paper 2: Health & Education

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Type 1 interferons

    Mains level: Paper 2- Emergency use approval of Virafin

    About the drug

    • It is used in treating people with chronic hepatitis B and C. 
    • The Drug Controller General of India (DCGI) granted emergency use approval for pharma major Zydus Cadila’s antiviral drug ‘Virafin’, to treat moderate COVID-19 disease in adults.
    • When administered early on during COVID, Virafin will help patients recover faster and avoid much of the complications.
    • It significantly reduces viral load when given early on and can help in better disease management.

    Findings of the clinical trials

    • A single dose subcutaneous regimen of the antiviral Virafin [a pegylated interferon alpha-2b (PegIFN)] will make the treatment more convenient for the patients.
    • When administered early on during COVID, Virafin will help patients recover faster and avoid much of the complications.
    • In the phase-3 trials, the drug was able to achieve “better clinical improvement in the patients suffering from COVID-19”.
    • A “higher proportion (91.15%) of patients administered the drug were RT-PCR negative by day seven as it ensures faster viral clearance”.
    • The drug reduced the duration for supplemental oxygen to 56 hours from 84 hours in moderate COVID-19 patients.

    How the drug works

    • Type I interferons are the body’s first line of defence against many viral infections.
    • In old people, the ability to produce interferon alpha in response to viral infections gets reduced, which might be the reason for higher mortality.
    • The drug when administered early during the disease can replace this deficiency and help in the recovery process.

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  • RBI Notifications

    RBI extends Ways and Means credit for States, UTs to Sept

    Prelims Only | Economics | Mains Paper 3: Indian Economy

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Consolidated Sinking Fund (CSF)

    Mains level: Paper 3- RBI extends WMA scheme

    About Ways and Means credit

    • Simply put, it is a facility for both the Centre and states to borrow from the RBI.
    • WMAs are temporary advances given by the RBI to the government to tide over any mismatch in receipts and payments.
    • Section 17(5) of the RBI Act, 1934 authorises the central bank to lend to the Centre and state governments subject to their being repayable “not later than three months from the date of the making of the advance”.

    Extension of the scheme

    • The RBI decided to continue with the existing interim Ways and Means Advances (WMA) scheme limit of ₹51,560 crore for all States/ UTs shall for six months given the prevalence of COVID-19.
    • Based on the recommendations of the Advisory Committee on WMA to State Governments, 2021 — chaired by Sudhir Shrivastava — the RBI had revised the WMA Scheme of States and Union Territories (UTs).
    • The WMA limit arrived at by the Committee based on total expenditure of States/ UTs, works out to ₹47,010 crore. 

    What RBI said about SDR

    • The RBI further said Special Drawing Facility (SDF) availed by state governments and UTs will continue to be linked to the quantum of their investments in marketable securities issued by the Government of India.
    • The net annual incremental investments in Consolidated Sinking Fund (CSF) and Guarantee Redemption Fund (GRF) will continue to be eligible for availing of SDF, without any upper limit.
    • CSF and GRF are reserve funds maintained by some State Governments with the Reserve Bank of India.

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  • Animal Husbandry, Dairy & Fisheries Sector – Pashudhan Sanjivani, E- Pashudhan Haat, etc

    Brucellosis: Preventive measures launched

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Health and Animal Husbandry teams have launched preventive measures and initiated an epidemiological investigation, after one case of brucellosis, was confirmed in a prisoner.

    • The infection is passed on to humans through the ingestion of unpasteurized milk and milk products or contact with animal secretions.

    Brucellosis:

    • Brucellosis is a bacterial disease that mainly infects cattle, swine, goats, sheep and dogs.
    • Humans can get infected if they come in direct contact with infected animals or by eating or drinking contaminated animal products or by inhaling airborne agents.
    • According to the WHO, most cases of the disease are caused by ingesting unpasteurised milk or cheese from infected goats or sheep.

    Symptoms:

    • Fever, sweats, malaise, anorexia, headache and muscle pain
    • While some signs and symptoms can last for long periods of time, others may never go away.
    • These include recurrent fevers, arthritis, swelling of the testicles and scrotum area, swelling of the heart, neurologic symptoms, chronic fatigue, depression and swelling of the liver or spleen.
    • Human to human transmission of the virus is rare.

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  • Global Energy Review 2021 report

    Prelims Only | Enviro & Biodiversity | Mains Paper 3: Conservation, Environmental Pollution & Degradation, Eia

    Initial estimates for 2020 energy demand and CO2 emission was released recently in an annual report Global Energy Review by International Energy Agency (IEA).

    https://www.world-nuclear-news.org/BlankSiteASPX/media/WNNImported/mainimagelibrary/corporate%20branded/Global-Energy-Review-2021-(IEA).jpg?ext=.jpg

    • The Global Energy Review is annual update on the latest trends in world energy and CO2 emissions.
    • It covers all the main fuels and technologies, providing insights across regions, economies and countries.

    Highlights of the report:

    • Global energy-related carbon dioxide (CO2) emissions are on course to surgeby 1.5 billion tonnes in 2021 driven by in the resurgence of coal use in the power sector.
      • The second-largest increase in history.
      • This would be the biggest annual rise in emissions since 2010, during the carbon-intensive recovery from the global financial crisis.
    • CO2 emissions will increase by almost five per cent in 2021 to 33 billion tonnes.
      • The key driver is coal demand, which is set to grow by 4.5 per cent, surpassing its 2019 level and approaching its all-time peak from 2014, with the electricity sector accounting for three-quarters of this increase.
    • Global energy demand is set to increase by 4.6 per cent in 2021, led by emerging markets and developing economies, pushing it above its 2019 level.
    • Demand for all fossil fuels is on course to grow significantly in 2021, with both coal and gas set to rise above their 2019 levels.
    • Oil is also rebounding strongly but is expected to stay below its 2019 peak, as the aviation sector remains under pressure.
      • More than 80 per cent of the projected growth in coal demand in 2021 is set to come from Asia, led by China.
    • Electricity generation from renewables is set to leap by over eight per cent in 2021.
    • The biggest contribution to that growth comes from solar and wind.
      • Electricity generation from wind is projected to grow by 275 terawatt-hours, or around 17 per cent, from last year.
      • Electricity generation from solar PV is expected to increase by 145 terawatt-hours, up almost 18 per cent from last year.
      • Their combined output is on track to reach more than 2800 terawatt-hours in 2021.
    • Renewables are set to provide 30 per cent of electricity generationworldwide in 2021.
    • China is expected to account for almost half of the global increase in electricity generation from renewables, followed by the US, the European Union and India.

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  • India ranks 87th in global energy transition index

    Prelims Only | Economics | Mains Paper 3: PDS, Buffer Stock & Food Security

    India has been ranked at the 87th position among 115 countries in the Energy Transition Index (ETI).

    • The latest report is based on a revised ETI methodology that takes into account recent changes in the global energy landscape and the increasing urgency of climate change action.
    • 92 out of 115 countries tracked on the ETI increased their aggregate score over the past 10 years, which affirms the positive direction and steady momentum of the global energy transition

    Highlights of the report:

    • The top 10 countries in the index are Western and Northern European countries.
    • Sweden is in the first position followed by Norway (2nd) and Denmark (3rd).
    • Other countries in the top 10 are Switzerland (4), Austria (5), Finland (6), the United Kingdom (7), New Zealand (8), France (9) and Iceland (10).
    • China (68) and India (87), which collectively account for a third of global energy demand, have both made strong improvements over the past decade, despite coal continuing to play a significant role in their energy mix.
      • “China”s improvements primarily result from reducing the energy intensity of the economy, gains in decarbonising the energy mixthrough the expansion of renewables and strengthening the enabling environment through investments and infrastructure.
    • Zimbabwe is the last ranked country.

    India specific highlights:

    • India has been ranked at the 87th position among 115 countries.
    • India has targeted improvements through subsidy reforms and rapidly scaling energy access, with a strong political commitment and regulatory environment for the energy transition.

    About the Energy Transition Index (ETI):

    • ETI is a report from World Economic Forum (WEF).
    • It is an annual ranking.
    • The index tracks nations on the current performance of their energy systems across various aspects.
    • The index benchmarks 115 countries on the current performance of their energy systems across three dimensions :
      1. Economic development and growth
      2. Environmental sustainability
      3. Energy security and access indicators — and their readiness to transition to secure, sustainable, affordable, and inclusive energy systems.

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