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Innovations in Biotechnology and Medical Sciences

Bistability in Pseudomonas aeruginosa and the glpD Gene 

Why in the News?

German researchers found that P. aeruginosa bacteria can switch a key gene (glpD) on or off, even though the bacteria are genetically identical — a survival trick called epigenetic bistability.

Bistability in Pseudomonas aeruginosa and the glpD Gene 

About Pseudomonas aeruginosa:

  • Nature: Rod-shaped bacterium found in soil, water, and hospital environments.
  • Pathogen Type: Opportunistic; infects mainly those with weakened immunity.
  • Resistance: Forms biofilms (protective layers), making it highly resistant to antibiotics.
  • Genetic Flexibility: Large genome (~6,000 genes) allows adaptation to diverse environments.

Impact on Humans:

  • Hospital Infections: Leading cause of hospital-acquired infections.
  • Vulnerable Groups: Burn patients, catheter users, cystic fibrosis patients.
  • Diseases Caused: Keratitis (eye infection), urinary tract infections, pneumonia, bloodstream infections.
  • Mortality: Strong antibiotic resistance makes treatment difficult, leading to high hospital deaths.

Recent Research Findings:

  • Discovery: German researchers identified bistable expression of the glpD gene (active in some cells, inactive in others).
  • Survival Advantage: This variability helps bacteria survive hostile conditions and trigger infections even from small populations.
  • Experiments:
    • Cells with glpD active were more lethal in moth larvae and mouse immune models.
    • Cells without glpD showed reduced infection ability.
  • Significance: On–off switching of glpD is a survival and infection strategy; targeting this mechanism may lead to new treatments for resistant infections.
[UPSC 2010] Which bacterial strain, developed from natural isolated by genetic manipulations, can be used for treating oil spills?

Options: (a) Agrodbacterium (b) Clostridium (c) Nitrosomonas (d) Pseudomonas*

 

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The Crisis In The Middle East

In news: International Criminal Court (ICC) 

Why in the News?

The Trump administration sanctioned judges and prosecutors of the International Criminal Court (ICC) over arrest cases involving Israeli leaders and past probes into U.S. officials.

About the International Criminal Court (ICC):

  • Established: 2002 under the Rome Statute (1998); headquartered at The Hague, Netherlands.
  • Nature: First permanent international court to try individuals for grave crimes.
  • Jurisdiction over 4 core crimes:
    1. Genocide
    2. Crimes against humanity
    3. War crimes
    4. Crime of aggression
  • Members: 124 States Parties
    • NON-members: India, China, USA, Russia, Israel, Ukraine
  • Structure:
    • Office of the Prosecutor – investigates and prosecutes cases.
    • 18 Judges – elected for 9 years.
    • Assembly of States Parties – governs ICC administration.
    • Trust Fund for Victims, Detention Centre
  • Languages: English, French, Arabic, Chinese, Russian, Spanish
  • Funding: Annual budget (2025) ~ €195 million (mostly from member states)

Jurisdiction and Reach of an ICC Warrant:

  • Applicability:
    • Crimes by nationals of member states
    • Crimes committed on member state territory
    • UNSC referrals can extend jurisdiction to non-member states (e.g., Libya, Darfur)
  • Obligations on States:
    • Member states must execute arrest warrants and cooperate fully.
    • Non-compliance can be reported to Assembly of States Parties or UN Security Council (for UNSC referrals)
  • Challenges:
    • ICC lacks an independent enforcement mechanism
    • Non-members (e.g., US, Russia) are not bound to cooperate
    • Political and diplomatic constraints hinder the execution of warrants
  • Special Mechanisms: ICC established an Arrest Working Group (2016) to enhance warrant enforcement through better intelligence-sharing.
[UPSC 2022] Which one of the following statements best reflects the issue with Senkaku Islands, sometimes mentioned in the news ?

Options:

(a) It is generally believed that they are artificial islands made by a country around South China Sea.

(b) China and Japan engage in maritime disputes over these islands in East China Sea. *

(c) A permanent American military base has been set up there to help Taiwan to increase its defence capabilities.

(d) Though International Court of Justice declared them as no man’s land, some South-East Asian countries claim them.

 

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Minority Issues – SC, ST, Dalits, OBC, Reservations, etc.

‘Creamy Layer’ condition in OBC Quota

Why in the News?

The government is considering measures to ensure uniform application of the ‘creamy layer’ condition in OBC reservations across central and state government jobs, public sector enterprises, universities, and autonomous bodies.

About the Concept of Creamy Layer:

  • Origin: Emerged from Indra Sawhney vs Union of India (1992); excluded affluent Other Backward Class (OBC) groups from reservations.
  • 1993 DoPT Rules: Defined creamy layer – children of Group A/Class I officers, early-promoted officials, Group B parents, senior armed forces, high constitutional functionaries, professionals, traders, and large landowners.
  • Income Criteria:
    • Ceiling: ₹1 lakh in 1993, revised to ₹8 lakh in 2017.
    • Exclusions: Salary and agricultural income not counted.

2004 Clarification & Implementation Issues:

  • Clarification: DoPT directed separate assessment of salary and other income (except agriculture).
  • Rule: If either exceeded limit (₹2.5 lakh then) for 3 consecutive years → creamy layer.
  • Problem: Poor enforcement (2004–14) due to political sensitivities; stricter checks after 2014.
  • Impact: Between CSE 2015–23, over 100 OBC caste certificates rejected under new interpretations.

Equivalence Efforts:

  • Consultations: Involved Social Justice, Education, Law, Labour Ministries, DoPT, NITI Aayog, NCBC.
  • Goal: Standardise creamy layer rules across universities, Public Sector Undertakings (PSUs), and autonomous bodies.
  • Proposal: Retrospective relief suggested by Home Minister Amit Shah and NCBC.

Key Proposals Under Consideration:

  • University Teachers: Salaries start at Group A-equivalent → children to be creamy layer.
  • Autonomous Bodies: Posts aligned with central pay scales.
  • Non-Teaching Staff: Categorisation based on equivalence with government jobs.
  • PSU Executives: Already included since 2017; those ≤₹8 lakh excluded.
  • Aided Institutions: Staff categorised based on parity with govt. employees.

Likely Beneficiaries:

  • Lower Govt. Staff: Children of employees earning just above ₹8 lakh gain most.
  • Correction of Anomalies: Ensures parity between teachers and aided staff.
  • State PSU Issues: Fixes cases like fuel pump attendants in PSUs being declared creamy layer.
  • Private Sector: No change; creamy layer based only on income/wealth criteria.
[UPSC 2023] Consider the following organizations/bodies in India:

1. The National Commission for Backward Classes

2. The National Human Rights Commission

3. The National Law Commission

4. The National Consumer Disputes Redressal Commission

How many of the above are constitutional bodies?

Options: (a) Only one *(b) Only two (c) Only three (d) All four

 

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Electoral Reforms In India

Office of the Chief Election Commissioner (CEC)

Why in the News?

The Opposition (INDI Alliance bloc) is considering moving a motion of removal of the Chief Election Commissioner (CEC) in Parliament.

About Election Commission of India (ECI):

  • Establishment: Permanent constitutional body set up on 25 January 1950 (National Voters Day).
  • Constitutional Basis: Articles 324–329, Part XV of the Constitution.
  • Mandate: Conducts elections to Lok Sabha, Rajya Sabha, State Legislative Assemblies, and the offices of President and Vice President.
  • Structure: Since 1993, functions as a three-member body with Chief Election Commissioner (CEC) and two Election Commissioners.
  • Status of CEC: Same salary, status, and perks as a judge of the Supreme Court of India.

Appointment to ECI:

  • Law: Chief Election Commissioner and Other Election Commissioners (Appointment, Conditions of Service and Term of Office) Act, 2023 (replaced 1991 Act).
  • Appointing Authority: President of India.
  • Selection Committee: Prime Minister (Chairperson), Leader of Opposition in Lok Sabha, and a Union Cabinet Minister nominated by the Prime Minister.
  • Eligibility: Must have served as a Secretary-level officer in Government of India with proven integrity and election management experience.
  • Tenure: 6 years or until 65 years of age, whichever is earlier.

Removal:

  • CEC: Removed like a Supreme Court judge (Article 324(5)) on grounds of proved misbehaviour or incapacity. Requires a motion passed by two-thirds majority in both Houses of Parliament and Presidential order.
  • Other Election Commissioners: Removed only on recommendation of the Chief Election Commissioner.
[UPSC 2012] Consider the following statements with reference to India:

1. The Chief Election Commissioner and other Election Commissioners enjoy equal powers but receive unequal salaries

2. The Chief Election Commissioner is entitled to the same salary as in provided to a judge of the Supreme Court

3. The Chief Election Commissioner shall not be removed from his office except in like manner and on like grounds as a judge of the Supreme Court

4. The term of office of the Election Commissioner is five years from the date he assumes his office or till the day he attains the age of 62 years, whichever is earlier

Which of these statements are correct?

Options: (a) 1 and 2 (b) 2 and 3* (c) 1 and 4 (d) 2 and 4

 

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Food Procurement and Distribution – PDS & NFSA, Shanta Kumar Committee, FCI restructuring, Buffer stock, etc.

[pib] “Anna-Chakra” Supply Chain Optimisation Tool for PDS 

Why in the News?

The Union Minister of State for the Ministry of Consumer Affairs, Food and Public Distribution has provided crucial information regarding the Anna-Chakra Tool to the Parliament.

About Anna-Chakra:

  • Purpose: Digital tool to optimise supply chain of the Public Distribution System (PDS).
  • Developed by: World Food Programme (WFP) and Foundation for Innovation and Technology Transfer (IIT-Delhi).
  • Implementation: Adopted in 30 States/UTs, except Manipur.
  • Coverage: Supports 4.37 lakh Fair Price Shops and 6,700 warehouses.
  • Savings: Reduces logistics/fuel costs, saving about ₹250 crore annually.
  • Environmental Impact: Route optimisation reduces travel distance by 15–50%, cutting CO₂ emissions.

Back2Basics: Public Distribution System (PDS) in India:

  • Objective: Provides subsidised food grains to poor households, ensuring food security.
  • History: Originated in inter-war years; expanded after 1960s food shortages.
  • Reforms: Revamped PDS (1992) extended coverage to rural and poverty-prone areas.
  • Structure:
    • Centre (FCI) – procurement, storage, transportation, bulk allocation.
    • States – distribute food grains to families via Fair Price Shops.
  • Coverage: Serves ~800 million people through 5 lakh+ Fair Price Shops.
  • Items Distributed: Wheat, rice, sugar, kerosene; some states add pulses and oils.
  • Significance: Shields poor households from food price shocks and economic distress.

 

[UPSC 2008] Consider the following statements:

1. Regarding the procurement of food grains, Government of India follows a procurement target rather than an open-ended procurement policy.

2. Government of India announces minimum support prices only for cereals.

3. For distribution under Targeted Public Distribution System (TPDS), wheat and rice are issued by the Government of India at uniform Central issue prices to the States/Union Territories.

Which of the statements given above is/are correct?”

Options: (a) 1 and 2 (b) 2 only (c) 1 and 3* (d) 3 only

 

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Capital Markets: Challenges and Developments

Minimum Public Shareholding (MPS)

Why in the News?

SEBI has released a consultation paper proposing changes in Minimum Public Shareholding (MPS) and Minimum Public Offer (MPO) norms for listed companies.

What is Minimum Public Offer (MPO)?

  • Meaning: When a company launches an Initial Public Offer (IPO), it must sell a minimum number of shares to the public.
  • Analogy: Like a new shop ensuring enough goods are displayed for customers — otherwise trading is thin and controlled by a few.

What is Minimum Public Shareholding (MPS)?

  • Concept: A company is like a cake. Promoters (founders/owners) usually keep most of it, but SEBI mandates at least 25% must be shared/sold with the public.
  • Purpose:
    • Broader ownership and participation.
    • Fairer prices by reducing manipulation.
    • Greater accountability of companies.

What SEBI is proposing?

  • Flexibility: Large companies find it difficult to release big chunks of shares at once; rules will be eased.
  • Extended Timelines:
    • Companies valued at ₹50,000–1,00,000 crore now get up to 10 years (instead of 5) to meet 25% MPS.
    • They must reach 15% in 5 years first, then 25% in 10 years.
  • Reduced Burden: For very large companies, the initial Minimum Public Offer (MPO) will be lowered.

Significance of the Move:

  • Market Stability: Selling too many shares too quickly is like flooding the market — prices may fall even if the company is strong.
  • Benefits:
    • More big companies will list in India.
    • Investors can enter gradually without sudden shocks.
    • Encourages fund-raising while maintaining fair trading.
[UPSC 2024] Consider the following statements:

I. India accounts for a very large portion of all equity option contracts traded globally, thus exhibiting a great boom.

II. India’s stock market has grown rapidly in the recent past, even overtaking Hong Kong’s at some point in time.

III. There is no regulatory body either to warn small investors about the risks of options trading or to act on unregistered financial advisors in this regard.

Which of the statements given above are correct?”

Options: (a) I and II only * (b) II and III only (c) I and III only (d) I, II and III

 

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Modern Indian History-Events and Personalities

Young Bengal Movement and Henry Derozio 

Why in the News?

This newscard is an excerpt from the article originally published in The Hindu.

Young Bengal Movement and Henry Derozio 

Who was Henry Vivian Louis Derozio?

  • Birth–Death: Born 1809, died- 22 in 1831; Indo-Portuguese origin.
  • Identity: Radical thinker, poet, and educator in British India.
  • Recognition: Called the first national poet of modern India; pioneer of Anglo-Indian poetry.
  • Influences: Inspired by Enlightenment ideals and the French Revolution.
  • Career: Became lecturer at Hindu College, Calcutta in 1826 at just 17.
  • Role: Inspired students with rationalism, liberty, and free thought.
  • Writings: Poems (1827), The Fakeer of Jungheera (1828), and To India – My Native Land (first modern patriotic poem in English).
  • Themes: Expressed India’s decline with images of a caged eagle and a broken instrument; advocated freedom and abolition of slavery.
  • Dismissal: Removed from Hindu College in 1831 on charges of spreading atheism.

The Young Bengal Movement: 

  • Formation: Radical group of his students, also called Derozians.
  • Association: Founded the Academic Association, debating social and political reform.
  • Ideals: Advocated rationalism, women’s rights, freedom of thought; opposed caste, superstition, idolatry.
  • Political Role: In 1843, with George Thompson, formed India’s first political party – Bengal British India Society.
  • Notable Member: Radhanath Sikdar, mathematician who first calculated Mount Everest’s height and openly resisted colonial injustices.
  • Perception: Described by missionary Alexander Duff as a “new race of men”; historian Rosinka Chaudhuri called them India’s “first radicals.”
  • Legacy and Intellectual Impact:
    • Awakening: Though short-lived, the movement sparked Bengal’s intellectual revolution.
    • Seeds of Reform: Laid foundation for later reformist and nationalist currents.
    • Independence of Mind: Marked a sharp break from Macaulay’s vision of Anglicised Indians — Derozians were assertive and original.
[UPSC 2021] Who among the following was associated as Secretary with Hindu Female School which later came to be known as Bethune Female School?

Options: (a) Annie Besant (b) Debendranath Tagore (c) Ishwar Chandra Vidyasagar * (d) Sarojini Naidu

 

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Wildlife Conservation Efforts

Saltwater Crocodile Population Survey in Sundarbans

Why in the News?

A 2025 survey by the West Bengal Forest Department shows an increase in saltwater crocodile population in the Sundarbans Biosphere Reserve (SBR).

Saltwater Crocodile Population Survey in Sundarbans

About Saltwater Crocodile (Crocodylus porosus):

  • Largest living reptile and the largest of all crocodilians.
  • Males grow much larger than females; females usually 2.5–3 m in length.
  • Habitat: mangrove forests, swamps, rivers, and coastal waters; tolerant of varying salinity.
  • Distribution in India: Odisha, West Bengal (Sundarbans), Andaman & Nicobar Islands.
  • Behaviour: Apex predator, feeds on carcasses and diverse prey; communicates through barks, hisses, growls, chirps.
  • Conservation Status:
    • IUCN Red List: Least Concern.
    • CITES: Appendix I (except populations of Australia, Indonesia, PNG → Appendix II).
    • Wildlife Protection Act (1972): Schedule I.
  • Conservation Efforts: Bhagabatpur Crocodile Project (1976, West Bengal) – breeding and conservation programme; 577 crocodiles released till 2022.

Other Crocodile Species in India:

  • Gharial: Critically Endangered; survives in only 2% of former range; Found in small stretches of Chambal and a few other rivers.
  • Mugger/Marsh Crocodile: Vulnerable; found in freshwater lakes, rivers, marshes.

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Electoral Reforms In India

The Constitution (130th Amendment) Bill, 2025

Why in the News?

The Union Home Minister is set to introduce three bills in the Lok Sabha to provide legal framework for removal of the Prime Minister, Union Ministers, Chief Ministers and Ministers in States and UTs who are “arrested and detained in custody on account of serious criminal charges.”

Which are the three Bills?

  1. 130th Constitutional Amendment Bill, 2025 (discussed below)
  2. Jammu and Kashmir Reorganisation (Amendment) Bill, 2025 – Provides clarity on removal of CM and Ministers in J&K.
  3. Government of Union Territories (Amendment) Bill, 2025 – Defines similar provisions for Puducherry and other UTs.

About the 130th Constitutional Amendment Bill, 2025:

  • Scope: Applies to Prime Minister, Chief Ministers, and Ministers at Union, State, and Union Territory levels.
  • Grounds for Removal: Arrest and detention for 30 consecutive days for an offense punishable by five years or more.
  • Reappointment: Possible after release from custody.
  • Objective: Prevent prolonged tenure of arrested leaders in office (e.g., recent case involving Delhi CM Arvind Kejriwal).

Amendments proposed to the following Articles:

Current Provision Limitation Changes Proposed
Article 75 (Union – PM & Union Ministers) PM appointed by President; Ministers appointed on PM’s advice. They hold office during the pleasure of the President. Removal is political (loss of confidence, resignation, dismissal). No explicit mechanism to remove PM/Ministers if detained/arrested for long periods. New provision: If PM or any Union Minister is detained in custody for 30 consecutive days for a serious offense (≥5 years punishment), they must resign by 31st day or automatically cease to hold office. They may be reappointed after release.
Article 164 (States – CM & State Ministers) CM appointed by Governor; Ministers appointed on CM’s advice. They hold office during the pleasure of the Governor. Council of Ministers collectively responsible to State Assembly. No clear rule for automatic removal if CM/Ministers remain in custody. Similar to Union level: If CM or Minister is detained in custody for 30 consecutive days under serious charges (≥5 years punishment), they automatically lose office. Reappointment allowed after release.
Article 239AA (Union Territory of Delhi – CM & Ministers) Special status for Delhi (NCT). CM and Council of Ministers aid & advise LG. They hold office as per political responsibility to the Assembly. No explicit provision for automatic removal on detention. A new Section 5A to be inserted: CM/Ministers of NCT of Delhi cease office if detained for 30 days under serious charges (≥5 years). Reappointment possible after release.

Rationale and Significance:

  • At present, the Constitution has no provision for automatic removal of ministers in custody.
  • Bill ensures that office bearers uphold public trust and do not undermine governance during detention.
  • The statement of objects emphasized that elected representatives must rise above political interests and maintain conduct beyond suspicion.
  • Promotes integrity of democracy by aligning ministerial positions with constitutional morality and accountability.
[UPSC 2020] Consider the following statements:

1. According to the Constitution of India, a person who is eligible to vote can be made a minister in a State for six months even if he/she is not a member of the Legislature of that State.

2. According to the Representation of People Act, 1951, a person convicted of a criminal offence and sentenced to imprisonment for five years is permanently disqualified from contesting an election even after his release from prison.

Options: (a) 1 only (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2*

 

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Electoral Reforms In India

When can Courts order a Recount of Votes?

Why in the News?

The Supreme Court for the very first time has recounted EVM votes on its premises and overturned a Haryana sarpanch election result.

Legal Framework for Challenging Election Results:

  • Parliamentary, Assembly, State Council elections: Validity can be challenged by filing an election petition in the High Court of the state where the election was held.
  • Local government elections: Petitions must be filed at district-level civil courts.
  • Eligibility to file: Only a candidate or elector related to the election can file.
  • Timeframe: Petition must be filed within 45 days of result declaration.
  • Petition requirements:
    • Must contain concise statement of material facts.
    • Allegations of “corrupt practices” must include names of individuals, dates, and locations.
  • Judicial Approach:
    • SC considers corrupt practices as quasi-criminal, requiring high standard of proof.
    • Vague or ambiguous petitions are dismissed.
  • Legal Basis:
    • Representation of the People Act, 1951.
    • State Panchayat Raj Acts.

Grounds for Invalidating an Election:

Courts can void an election on:

  • Bribery or undue influence, e.g., hiding criminal antecedents or promoting enmity.
  • Candidate disqualified/unqualified on the election date.
  • Improper rejection of nomination paper.
  • Improper acceptance of nomination or improper reception/rejection of votes, if shown to materially affect results.
  • Non-compliance with Constitution or election laws/rules, if it materially impacted the outcome.

When can Courts order Recount of Votes?

  • A recount is a possible judicial remedy but not granted lightly.
  • Seen as affecting vote secrecy, which is vital to free and fair elections.
  • Courts order recounts only if:
    • Petitioner presents specific material facts.
    • Evidence shows a prima facie case of probable counting error.
    • Recount is deemed necessary for justice.
  • Normally conducted at election location.
  • Exception: Panipat case, where SC recounted votes in its own premises.

Can Courts declare a new Winner?

  • Rare, but courts can declare a new winner if:
    • Evidence shows petitioner (or another candidate) actually had majority of valid votes.
    • Or petitioner proves they would have won but for votes gained through corrupt practices.
  • Requires concrete, quantifiable evidence of tainted votes.
  • Example: In Feb 2024 Chandigarh mayoral election, SC declared a new winner after:
    • Presiding officer wrongly invalidated 8 paper ballots.
    • All votes had been cast for the losing candidate.
    • SC restored them as valid, making the losing candidate the winner.
[UPSC 2004] Consider the following tasks:

1. Superintendence, direction and conduct of free and fair elections.

2. Preparation of electoral rolls for all elections to the Parliament, State Legislatures and the Office of the President and the Vice-President.

3. Giving recognition to political parties and allotting election symbols to political parties and individuals contesting the election.

4. Proclamation of final verdict in the case of election disputes.

Which of the above are the functions of the Election Commission of India?

Options: (a) 1, 2 and 3* (b) 2, 3 and 4 (c) 1 and 3 (d) 1, 2 and 4

 

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Innovations in Sciences, IT, Computers, Robotics and Nanotechnology

How are Soaps and Detergents manufactured?

Why in the News?

This newscard is an excerpt from the original article published in ‘The Hindu’.

About Soap:

  • Composition: Soap is sodium (Na) or potassium (K) salt of fatty acids derived from vegetable oils or animal fats.
  • Formula: Solid soaps are RCOONa, liquid soaps are RCOOK.
  • Function: Cleansing agent due to dual hydrophilic (water-attracting) and hydrophobic (oil-attracting) nature.
  • History: Used since 2800 BC in Mesopotamia and ancient India (soap nuts, bark, flowers). Became mass-produced during the Industrial Revolution, initially a luxury.

Soap-Making Process

  • Raw Materials: Oils such as coconut, olive, palm, sunflower provide triglycerides.
  • Hydrolysis: Oils hydrolysed with hot water under pressure → fatty acids + glycerin.
  • Saponification: Fatty acids react with sodium hydroxide (NaOH) → soap (RCOONa) + water.
  • Processing: Soap dried into noodles, blended with perfumes, colours, fillers, additives.
  • Shaping: Extruded, cut, and stamped into bars.
  • Quality: Total Fatty Matter (TFM) indicates quality; higher TFM = better cleansing.
  • Production Scale: Modern automated lines make 600–700 soaps per minute.

Ecological Impact of Soap

  • Biodegradability: Traditional soaps are biodegradable and safer for the environment.
  • Detergents: Synthetic alternatives developed during World War I oil shortages; more efficient but harmful.
  • Pollution: Surfactants and phosphates in detergents cause nutrient pollution and persist in ecosystems.
[UPSC 2002] Consider the following statements:

Assertion (A) Synthetic detergents can lather well in hard water.

Reason (R): Synthetic detergents form soluble calcium and magnesium salts with hard water.

Which one of the following is correct in respect of the above statements?

Options:

(a) Both A and R are individually true and R is the correct explanation of A *

(b) Both A and R are individually true but R is not a correct explanation of A

(c) A is true but R is false

(d) A is false but R is true

 

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Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

Primary Amoebic Meningoencephalitis (PAM)

Why in the News?

Kerala’s health department has issued an alert in Kozhikode district after three consecutive cases of the rare and highly fatal disease Primary Amoebic Meningoencephalitis (PAM) were reported.

About Primary Amoebic Meningoencephalitis (PAM):

  • Cause: Rare and usually fatal infection caused by Naegleria fowleri, known as the “brain-eating amoeba.”
  • Habitat: Thrives in warm freshwater up to 46°C (115°F).
  • Entry: Enters through the nose during swimming or water activities, travels via olfactory nerve to the brain.
  • Impact: Destroys brain tissue and causes severe swelling.
  • Transmission: Not communicable from person to person.
  • Symptoms: Headache, fever, nausea, vomiting, stiff neck, confusion, seizures, hallucinations, coma, and death.
  • Progression: According to the Centers for Disease Control and Prevention (CDC), most cases result in death within 1–18 days of symptom onset.

Diagnosis and Treatment:

  • Diagnosis:
  • Treatment:
    • No single therapy effectively established.
    • Managed per CDC guidelines using drug combinations such as: Medical interventions typically involve a combination of drugs, including amphotericin B, azithromycin, fluconazole, rifampin, miltefosine, and dexamethasone.
[UPSC 2008] Consider the following statements:

1. Femur is the longest bone in the human body.

2. Cholera is a disease caused by bacteria.

3. ‘Athlete’s foot’ is a disease caused by virus. Which of the statements given above are correct?

Options: (a) 1 and 2 * (b) 2 and 3 (c) 1 and 3 (d) 1, 2 and 3

 

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Innovations in Biotechnology and Medical Sciences

Scientists turn E. Coli Bacteria into a Bio-Sensor

Why in the News?

Researchers from UK and China have developed a bioelectronic device where genetically engineered E. Coli bacteria act as self-powered chemical bio-sensor.

About Escherichia coli (E. coli) Bacteria:

  • Overview: Gram-negative, rod-shaped bacterium that inhabits the lower intestine of warm-blooded animals.
  • Family: Belongs to the Enterobacteriaceae family.
  • Harmless vs Pathogenic: Most strains are harmless, but some (e.g., E. coli O157:H7) cause severe foodborne illness, diarrhoea, and kidney complications.
  • Gut Role: Contributes to vitamin K₂ synthesis and maintains gut microbiota balance.
  • Transmission: Pathogenic strains spread via contaminated food, water, or direct contact, leading to outbreaks.
  • Diagnostic Importance: Presence in water is a key indicator of faecal contamination.

Bio-Sensors Generated Using E. coli

  • Innovation: Genetically engineered E. coli used as self-powered chemical biosensors.
  • Mechanism: Detect compounds, process signals, and produce electrical outputs compatible with low-cost electronics.
  • Modules:
    • Sensing Module: Detects target molecules.
    • Processing Module: Amplifies or modifies signals.
    • Output Module: Produces phenazines measurable via electrochemistry.
  • Applications:
    • Detected arabinose (plant sugar) within 2 hours.
    • Detected mercury ions in water at trace levels (below WHO safety limits) within 3 hours.
    • Demonstrated an “AND” logic gate, producing signals only when two molecules were present together.
  • Significance:
    • Cheaper, programmable, and robust alternative to enzyme-based biosensors.
    • Potential in environmental monitoring, water safety, medical diagnostics, and bioelectronics.
[UPSC 2010] Which bacterial strain, developed from natural isolated by genetic manipulations, can be used for treating oil spills?

(a) Agrodbacterium

(b) Clostridium

(c) Nitrosomonas

(d) Pseudomonas*

 

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Festivals, Dances, Theatre, Literature, Art in News

In news: Gugga Naumi Festival

Why in the News?

The Gugga Naumi festival was widely celebrated across northern states of India on 17th August.

About Gugga Naumi Festival:

  • Festival: Folk religious celebration in Rajasthan, Haryana, Punjab, Jammu & Kashmir, Uttar Pradesh, and northern states.
  • Timing: Observed on the ninth day of Krishna Paksha in Bhadrapad month, usually after Janmashtami.
  • Deity: Dedicated to Gugga (Gugga Pir / Gugga Zahir Pir / Guaaji), a Chauhan Rajput prince believed to control snakes.
  • Tradition: Reflects syncretic worship by Hindus and Muslims, showcasing folk religiosity beyond formal religion.

Key Features:

  • Duration: Begins on Rakhi and lasts nine days, with pilgrimages to Gugga Medi village in Hanumangarh, Rajasthan.
  • Rituals: Garudas (snake charmers and healers) carry Gugga Pir’s Chahad (standard).
  • Devotion: Pir ke Sole (songs) sung, fairs organised at shrines (Marhis).
  • Depiction: Gugga shown riding a blue horse, with blue and yellow flags.
  • Belief: Worshipped by mothers for children’s health, and by barren women for fertility blessings.
[UPSC 2018] Consider the following pairs: Tradition State

1. Chapchar Kut festival — Mizoram

2. Khongjom Parba ballad — Manipur

3. Thong-To dance — Sikkim

Which of the pairs given above is/are correct?

(a) 1 only (b) 1 and 2* (c) 3 only (d) 2 and 3

 

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Genetically Modified (GM) crops – cotton, mustards, etc.

Chalkiness in Rice and the Genetic Breakthrough

Why in the News?

Recently, Chinese scientists identified a key gene, Chalk9, that controls chalkiness in rice, offering a breakthrough for crop improvement.

About Chalk9 Gene in Rice:

  • Overview: Chalk9 is a gene found on chromosome 9 of rice.
  • Function: Encodes the enzyme E3 ubiquitin ligase, which regulates protein degradation.
  • Target Protein: Acts on OsEBP89, a regulator of starch-synthesis genes Wx and SSP.
  • Chalk9-L Variant: Promotes OsEBP89 degradation → prevents excess starch accumulation → results in low chalkiness and translucent grains.
  • Chalk9-H Variant: Fails to degrade OsEBP89 efficiently → leads to starch buildup → high chalkiness and brittle grains.

Significance:

  • Grain Quality: Chalkiness lowers milling recovery and reduces rice’s commercial value.
  • Genetic Solution: Discovery of Chalk9 offers a direct genetic tool to reduce chalkiness.
  • Breeding Advantage: Rice breeding programs can introduce Chalk9-L to produce premium low-chalk rice.
  • Economic Impact: Improves farmer income and enhances food security.
  • Consumer Preference: Meets demand for better quality, translucent rice varieties.
[UPSC 2022] Consider the following statements: DNA Barcoding can be a tool to :

1. assess the age of a plant or animal. 2. distinguish among species that look alike. 3. identify undesirable animal or plant materials in processed foods.

Which of the statements given above is/are correct?

Options: (a) 1 only (b) 3 only (c) 1 and 2 (d) 2 and 3*

 

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Innovations in Sciences, IT, Computers, Robotics and Nanotechnology

MIT Research of Ionic Liquids (ILs)

Why in the News?

MIT-led research suggests life may not need liquid water; ionic liquids (salts that stay liquid below 100°C) could support life on rocky super-Earths with volcanic activity and little water.

About Ionic Liquids (ILs):

  • Overview: Salts in liquid form below 100°C, composed entirely of ions.
  • Properties: Non-volatile, non-flammable, thermally stable, and tunable as hydrophobic or hydrophilic.
  • Structure: Unlike water (neutral molecules), ILs consist of ions and ion pairs.
  • Electrochemical Use: Excellent electrolytes with broad electrochemical windows.
  • Applications: Used in synthesis, catalysis, electrochemistry, extraction, biotechnology, and as green alternatives to volatile solvents.

Breakthrough Findings of MIT Study:

  • Life Without Water: Experiments showed life could potentially survive using ILs as solvents instead of water.
  • Natural Formation: Sulfuric acid mixed with nitrogen compounds can naturally form ILs.
  • Exoplanet Link: Such ILs may exist on rocky super-Earths with volcanic activity and thin atmospheres.
  • Venus Research Origin: Discovery emerged from studying Venus, where sulfuric acid clouds interact with organic molecules to form ILs.
  • Biological Relevance: ILs can provide stable environments for biomolecules, supporting metabolism.

Significance of the Study:

  • Habitability Expansion: Broadens habitability definition beyond water-based models.
  • Biosignatures: Suggests new chemical markers for exoplanet life detection.
  • Venus Missions: Strengthens rationale for Venus’s exploration targeting IL-based chemistry.
  • Wider Habitable Zones: Implies more planets could host life than previously thought.
[UPSC 2015] The term ‘Goldilocks Zone’ is often seen in the news in the context of:

(a) the limits of habitable zone above the surface of the Earth

(b) regions inside the Earth where shale gas is available

(c) search for the Earth-like planets in outer space*

(d) search for meteorites containing precious metals

 

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Judicial Pendency

Supreme Court interventions in Civil–Criminal overlap Cases

Why in the News?

In August 2025, the Supreme Court intervened twice to prevent the misuse of criminal proceedings in essentially civil disputes.

About Civil and Criminal Cases:

  • Civil cases involve disputes between individuals or organisations and are mostly governed by Code of Civil Procedure, 1908 (CPC). The aim is to resolve rights and duties, usually through compensation (damages) or injunctions. Examples: property disputes, contract breaches, divorce, custody, money recovery.
  • Criminal cases involve offences against the state or society. The objective is punishment and deterrence. Initiated by the state prosecutor. Examples: theft, cheating, assault, murder.
  • Burden of proof:
    • Civil cases: Decided on a preponderance of probabilities (more likely than not).
    • Criminal cases: Guilt must be proven beyond reasonable doubt.
  • Dual Cases: Some acts can give rise to both civil and criminal liability. For dual proceedings, there must be proof of criminal intent before entering the commercial or personal relationship.
  • Timelines: Data from the National Judicial Data Grid (2025) shows civil cases are slower (avg. 4.91 years) compared to many criminal cases (70% disposed within a year).

Recent Supreme Court Actions:

  • Rajasthan plywood dispute case (Aug 13, 2025): SC held there was no criminal breach of trust in a simple sale transaction. Denial of pre-arrest bail by the High Court was overturned.
  • Allahabad HC case (Aug 4, 2025): SC criticised a judge for allowing criminal proceedings in a business transaction dispute, calling it a “mockery of justice”. The judge was temporarily barred from handling criminal cases, later reinstated after CJI intervention.
    • The SC clarified that civil disputes cannot be turned into criminal prosecutions unless fraud or criminal intent is clearly shown.
[UPSC 2016] With reference to the ‘Gram Nyayalaya Act’, which of the following statements is/are correct?

1. As per the Act, Gram Nyayalayas can hear only civil cases and not criminal cases.

2. The Act allows local social activists as mediators/reconciliators.

Options: (a) 1 only (b) 2 only* (c) Both 1 and 2 (d) Neither 1 nor 2

 

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Modern Indian History-Events and Personalities

In news: British Conquest of Sindh

Why in the News?

The British conquest of Sindh in the 1840s was a key step in colonial expansion, reminding us that regions like Sindh, Punjab, and Bengal came under British rule long before the 1947 partition of India and Pakistan.

British Conquest of Sindh:

  • Sindh was annexed by the British in 1843 after the battles of Miani and Dubbo.
  • The resistance was led by Hosh Muhammad Sheedi, a general of the Talpur army and member of the African-origin Siddi community.
  • His defiance symbolised the first major armed resistance to British expansion in northwest India.

Political Background in Sindh:

  • Kalhora Dynasty (1701–1779): Founded by Mian Yar Muhammad Kalhoro, recognised by Mughals; ruled northern and central Sindh. Prosperous period but weakened by internal disputes.
  • Talpur Dynasty (1779–1843): Baloch Talpurs overthrew Kalhoras; consolidated Sindh under clan rule at Hyderabad and Khairpur.
  • Geopolitical Context: Sindh lay at the crossroads of British–French–Russian rivalry (The Great Game). Britain feared Russian advances through Iran and Afghanistan.
  • British Entry: East India Company forced treaties on Talpurs; captured Karachi (1839) after bombarding Manora fort.

British Advance and the Fall of Sindh:

  • Battle of Miani (17 Feb 1843): British under Sir Charles Napier defeated Mir Nasir Khan Talpur near Hyderabad.
  • Battle of Dubbo (24 Mar 1843): Hosh Muhammad Sheedi allied with Mir Sher Muhammad Talpur of Mirpur Khas. Sheedi raised the war cry “Marvesoon par Sindh na desoon” (I may die but will not give up Sindh). He was killed in action.
  • British Annexation: After Dubbo, Sindh was annexed into the Bombay Presidency. Talpur rule ended.
  • Aftermath: Within a decade, Punjab too was annexed (1849), bringing all of northwest India under British rule.

Legacy of Hosh Muhammad Sheedi:

  • Born into the household of Talpur rulers; of African-Siddi descent.
  • Valour acknowledged by both Indian and British chroniclers.
  • Became a folk hero of Sindh, remembered by Hindus and Muslims alike.
  • His legacy is central to the cultural memory of Sindh and highlights the role of the Siddi community in resisting colonialism.
[UPSC 2007] The ruler of which one of the following States was removed from power by the British on the pretext of misgovernance?

Options: (a) Awadh* (b) Jhansi (c) French (d) Satara

 

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Modern Indian History-Events and Personalities

Red Fort as the Venue for Independence Day

Why in the News?

On August 15, 2025, Prime Minister delivered the longest Independence Day speech (103 minutes) from the Red Fort, continuing a tradition started by Jawaharlal Nehru in 1947.

The fort’s choice as the venue reflects its historic role as Delhi’s seat of power and symbol of sovereignty.

About the Red Fort:

  • Construction: Built in 1648 by Mughal Emperor Shah Jahan as the palace fort of Shahjahanabad, his new capital.
  • Material: Enclosed by massive red sandstone walls with royal pavilions and apartments.
  • Water Feature: Contained the Nahr-i-Behisht (“Stream of Paradise”), a continuous water channel.
  • Architectural Value: Prime example of Mughal architecture, blending Islamic traditions with Indian craftsmanship.
  • Recognition: Declared a UNESCO World Heritage Site in 2007.

Historical Significance of Delhi and Red Fort:

  • Delhi’s Role: Seat of power for nearly a thousand years, regarded as “capital of all Hindustan” by Babur.
  • Shahjahanabad: Inaugurated in 1648 with the Red Fort at its centre.
  • Symbol of Sovereignty: Even after Mughal decline, Delhi remained central; East India Company minted coins in the emperor’s name.

1857 Revolt and British Authority:

  • Revolt Centre: Bahadur Shah Zafar was declared leader by sepoys in Delhi.
  • Aftermath: Fall of Delhi ended Mughal rule; Zafar was exiled.
  • Fort Damage: British converted Red Fort into a military garrison, destroying ~80% of interiors.
  • Imperial Authority: Delhi Durbars (1877, 1903, 1911) asserted British control before capital shifted from Calcutta to Delhi in 1911.

Significance of Red Fort for Independence Day:

  • INA Trials: Held in Red Fort in 1946, igniting nationalist fervour.
  • 1947 Ceremony: Jawaharlal Nehru hoisted the national flag on 15 August 1947 and gave the first Independence Day address.
  • Tradition: Since then, every Prime Minister hoists the flag and addresses the nation from its ramparts.
  • Symbolism: Site once stamped with colonial dominance, now reclaimed as a symbol of India’s sovereignty.
[UPSC 2021] What was the exact constitutional status of India on 26th January, 1950?

Options: (a) A democratic Republic (b) A Sovereign Democratic Republic* (c) A Sovereign Secular Democratic Republic (d) A Sovereign Socialist Secular Democratic Republic

 

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Animal Birth Control (ABC) Program

Why in the News?

The Supreme Court has recently called returning sterilised stray dogs to the streets under the Animal Birth Control (ABC) Program as “unreasonable and absurd” and ordered they be moved to shelters.

About Animal Birth Control (ABC) Program:

  • Purpose: Humane, scientifically proven method to control stray dog populations and reduce rabies.
  • Legal Basis: First under Animal Birth Control (Dogs) Rules, 2001 (under the Prevention of Cruelty to Animals Act, 1960); updated as Animal Birth Control Rules, 2023.
  • Development: Created with support from the World Health Organization (WHO).
  • Core Method: “Catch–sterilise–vaccinate–release” model; prohibits relocation or culling.
  • Implementation: Managed by municipalities, municipal corporations, and panchayats.
  • Authorisation: Only organisations recognised by the Animal Welfare Board of India (AWBI) can conduct programs.
  • Animal Birth Control Rules, 2023:
    • Implemented to comply with Supreme Court guidelines in Writ Petition No. 691 of 2009.
    • Assigns responsibility to local bodies (municipalities, corporations, panchayats) to conduct ABC programs for sterilisation and immunisation of stray dogs.
    • Prohibits relocation of stray dogs as a means of population control; instead, they must be sterilised and returned to the same area.
    • Only organisations recognised by the Animal Welfare Board of India (AWBI) can conduct ABC programs.

Key Features:

  • Sterilisation Target: Minimum 70% of stray dogs in an area within one reproductive cycle (~6 months).
  • Focus: Female sterilisation at a 70:30 female-to-male ratio.
  • Rabies Control: Mandatory rabies vaccination (ABC–ARV) for every sterilised dog.
  • Infrastructure: Kennels, veterinary facilities, vehicles, and hygienic shelters required.
  • Recordkeeping: Detailed records for catching, surgery, vaccination, and release.
  • Monitoring: State and local committees ensure compliance and handle complaints.
  • Legal Protection: Mass relocation or killing prohibited under the Prevention of Cruelty to Animals (PCA) Act, 1960.
[UPSC 2010] Consider the following statements:

1. Every individual in the population is equally susceptible host for Swine Flu.

2. Antibiotics have no role in the primary treatment of Swine Flu

3. To prevent the future spread of Swine Flu in the epidemic area, the swine (pigs) must all be culled.

Which of the statements given above is/are correct?

Options: (a) 1 and 2 only* (b) 2 only  (c) 2 and 3 only (d) 1, 2 and 3

 

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